/* EligibleTrials - calm, trustworthy medical identity.
   Palette: deep teal + soft slate on near-white; generous whitespace,
   readable serif headings over a clean sans body. Distinct from sibling sites. */

:root{
  --teal:#0e7c86;
  --teal-dark:#0a5a62;
  --teal-tint:#e6f3f4;
  --ink:#1c2733;
  --muted:#5b6b7a;
  --line:#dbe3e8;
  --bg:#f7fafb;
  --card:#ffffff;
  --warn-bg:#fff8e6;
  --warn-line:#e8d9a6;
  --amber:#8a6d1a;
  --ok:#137a4b;
  --radius:12px;
  --wrap:1080px;
}

*{box-sizing:border-box}
html{-webkit-text-size-adjust:100%}
body{
  margin:0;
  background:var(--bg);
  color:var(--ink);
  font:16px/1.6 -apple-system,BlinkMacSystemFont,"Segoe UI",Roboto,Helvetica,Arial,sans-serif;
}
h1,h2,h3{font-family:Georgia,"Times New Roman",serif;line-height:1.25;color:var(--ink);font-weight:600}
h1{font-size:1.9rem;margin:.2em 0 .4em}
h2{font-size:1.35rem;margin:1.6em 0 .5em}
h3{font-size:1.1rem;margin:1.2em 0 .4em}
a{color:var(--teal-dark);text-decoration:none}
a:hover{text-decoration:underline}
p{margin:.6em 0}
.wrap{max-width:var(--wrap);margin:0 auto;padding:0 20px}
.muted{color:var(--muted)}
.small{font-size:.86rem}

/* header */
header.site{background:var(--card);border-bottom:1px solid var(--line);position:sticky;top:0;z-index:20}
header.site .wrap{display:flex;align-items:center;justify-content:space-between;gap:16px;min-height:60px;flex-wrap:wrap}
.brand{font-family:Georgia,serif;font-weight:700;font-size:1.3rem;color:var(--teal-dark);display:flex;align-items:center;gap:9px}
.brand:hover{text-decoration:none}
.brand .mark{display:inline-block;width:26px;height:26px;border-radius:7px;background:var(--teal);position:relative}
.brand .mark::after{content:"";position:absolute;inset:7px;border:2.5px solid #fff;border-radius:50%;border-right-color:transparent;transform:rotate(35deg)}
.brand span{color:var(--teal)}
nav.main{display:flex;gap:20px;flex-wrap:wrap}
nav.main a{color:var(--muted);font-weight:500;font-size:.95rem}
nav.main a:hover{color:var(--teal-dark)}

/* disclaimer banner */
.disclaimer{background:var(--warn-bg);border:1px solid var(--warn-line);color:var(--amber);
  border-radius:var(--radius);padding:12px 16px;margin:18px 0;font-size:.9rem}
.disclaimer strong{color:#6d5410}

/* hero */
.hero{background:linear-gradient(160deg,var(--teal) 0%,var(--teal-dark) 100%);color:#eafafb;
  border-radius:var(--radius);padding:34px 30px;margin:22px 0}
.hero h1{color:#fff;margin-top:0}
.hero p{color:#d3eef0;max-width:62ch}
.hero .stat{display:inline-block;margin-top:14px;background:rgba(255,255,255,.14);
  border-radius:20px;padding:6px 14px;font-size:.92rem;color:#eafafb;margin-right:8px}

/* cards / grid */
.grid{display:grid;gap:14px;grid-template-columns:repeat(auto-fill,minmax(240px,1fr));margin:16px 0}
.card{background:var(--card);border:1px solid var(--line);border-radius:var(--radius);padding:16px 18px}
.card h3{margin:.1em 0 .3em}
.card .count{color:var(--teal-dark);font-weight:600}
a.card:hover{border-color:var(--teal);text-decoration:none;box-shadow:0 2px 10px rgba(14,124,134,.08)}

/* stat strip */
.stats{display:flex;gap:14px;flex-wrap:wrap;margin:16px 0}
.stats .box{background:var(--card);border:1px solid var(--line);border-radius:var(--radius);
  padding:14px 18px;min-width:130px;flex:1}
.stats .box .n{font-size:1.6rem;font-weight:700;color:var(--teal-dark);font-family:Georgia,serif}
.stats .box .l{font-size:.82rem;color:var(--muted);text-transform:uppercase;letter-spacing:.04em}

/* phase / tag chips */
.chips{display:flex;gap:8px;flex-wrap:wrap;margin:8px 0}
.chip{background:var(--teal-tint);color:var(--teal-dark);border-radius:16px;padding:4px 12px;
  font-size:.85rem;font-weight:500;border:1px solid #cfe6e8}
.chip .n{font-weight:700}

/* eligibility box */
.elig{background:var(--card);border:1px solid var(--line);border-radius:var(--radius);overflow:hidden;margin:16px 0}
.elig .row{display:flex;border-top:1px solid var(--line)}
.elig .row:first-child{border-top:0}
.elig .k{flex:0 0 190px;background:var(--teal-tint);padding:11px 16px;font-weight:600;color:var(--teal-dark);font-size:.92rem}
.elig .v{padding:11px 16px;flex:1}
@media(max-width:560px){.elig .row{flex-direction:column}.elig .k{flex-basis:auto}}

/* trial list */
.tlist{list-style:none;padding:0;margin:16px 0}
.tlist li{background:var(--card);border:1px solid var(--line);border-radius:var(--radius);
  padding:14px 16px;margin-bottom:10px}
.tlist li a.t{font-weight:600;font-size:1.02rem}
.tlist .meta{color:var(--muted);font-size:.86rem;margin-top:5px}
.tlist .meta b{color:var(--ink);font-weight:600}

/* screener form */
.screener{background:var(--card);border:1px solid var(--line);border-radius:var(--radius);padding:18px 20px;margin:18px 0}
.screener form{display:flex;gap:14px;flex-wrap:wrap;align-items:flex-end}
.screener label{display:flex;flex-direction:column;font-size:.85rem;color:var(--muted);gap:4px}
.screener input,.screener select{padding:9px 11px;border:1px solid var(--line);border-radius:8px;font-size:.95rem;background:#fff}
.btn{background:var(--teal);color:#fff;border:0;border-radius:8px;padding:10px 18px;font-size:.95rem;font-weight:600;cursor:pointer}
.btn:hover{background:var(--teal-dark)}
.btn.sec{background:#fff;color:var(--teal-dark);border:1px solid var(--line)}

/* criteria */
.criteria ul{margin:.3em 0;padding-left:1.3em}
.criteria li{margin:.3em 0}
.rawtext{white-space:pre-wrap;background:var(--card);border:1px solid var(--line);
  border-radius:var(--radius);padding:16px;font-size:.9rem;color:#33414f;max-height:520px;overflow:auto}

/* source line + official link */
.official{display:inline-block;background:var(--teal);color:#fff;border-radius:8px;padding:11px 18px;
  font-weight:600;margin:14px 0}
.official:hover{background:var(--teal-dark);text-decoration:none;color:#fff}
.source{font-size:.84rem;color:var(--muted);margin-top:20px;border-top:1px solid var(--line);padding-top:12px}

/* location list */
.locs{list-style:none;padding:0;margin:12px 0}
.locs li{padding:8px 0;border-bottom:1px solid var(--line);font-size:.93rem}
.locs li:last-child{border-bottom:0}
.locs .fac{font-weight:600}
.locs .place{color:var(--muted)}

table.states{border-collapse:collapse;width:100%;margin:12px 0;background:var(--card);border:1px solid var(--line);border-radius:var(--radius);overflow:hidden}
table.states th,table.states td{text-align:left;padding:9px 14px;border-bottom:1px solid var(--line);font-size:.93rem}
table.states th{background:var(--teal-tint);color:var(--teal-dark);font-weight:600}
table.states tr:last-child td{border-bottom:0}

/* footer */
footer.site{margin-top:40px;background:var(--card);border-top:1px solid var(--line);padding:24px 0;color:var(--muted);font-size:.88rem}
footer.site a{color:var(--muted)}
footer.site a:hover{color:var(--teal-dark)}

.breadcrumb{font-size:.85rem;color:var(--muted);margin:14px 0 4px}
.breadcrumb a{color:var(--muted)}
.noindex-note{font-size:.8rem;color:#a33;margin-top:6px}

/* honeypot: off-screen, only bots fill it */
.hp{position:absolute!important;left:-9999px;width:1px;height:1px;overflow:hidden}
.consent.optional{opacity:.85;font-size:.9em}

/* FDA drug-label reference section (factual, openFDA-cited) */
.fda-ref{background:var(--card,#fff);border:1px solid var(--line,#e2e2e2);border-left:4px solid var(--teal,#0e7c86);border-radius:var(--radius,10px);padding:16px 18px;margin:20px 0}
.fda-ref h2{margin-top:0}
.fda-facts{display:grid;grid-template-columns:max-content 1fr;gap:6px 18px;margin:10px 0 4px}
.fda-facts dt{font-weight:600;color:var(--teal-dark,#0a5a63)}
.fda-facts dd{margin:0}
.fda-indication{background:var(--teal-tint,#f0f9fa);border-radius:8px;padding:12px 14px;font-size:.95rem}