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A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)
NCT07033494 ·
Phase: Phase 2 ·
Ages: 50 Years to 85 Years ·
Sex: All (male and female)
· Texas: Beaumont, Cypress
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A Clinical Trial of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease
NCT07170150 ·
Phase: Phase 3 ·
Ages: 50 Years to 90 Years ·
Sex: All (male and female)
· Texas: Beaumont, Dallas, Fort Worth, Katy
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A Clinical Trial to Learn About the Effects of VHB937 in People With Early Alzheimer's Disease
NCT07094516 ·
Phase: Phase 2 ·
Ages: 50 Years to 85 Years ·
Sex: All (male and female)
· Texas: San Antonio
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A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease
NCT07011745 ·
Phase: Phase 3 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· Texas: Carrollton, Cypress, Mesquite, San Antonio
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A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-1)
NCT07011732 ·
Phase: Phase 3 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· Texas: El Paso
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A Study of Donanemab (LY3002813) in Participants Who Completed Study AACM (TRAILBLAZER-ALZ 3-EXT).
NCT07602582 ·
Phase: Phase 3 ·
Ages: 55 Years and older ·
Sex: All (male and female)
· Texas: Austin, Beaumont, Houston, Shavano Park
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A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)
NCT07589595 ·
Phase: Phase 2 ·
Ages: 55 Years to 85 Years ·
Sex: All (male and female)
· Texas: Beaumont, Dallas, Houston, Round Rock
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A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation
NCT05552157 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Texas: Dallas
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A Study of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease
NCT07169578 ·
Phase: Phase 3 ·
Ages: 50 Years to 90 Years ·
Sex: All (male and female)
· Texas: Dallas, Edinburg, Houston
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A Study of a Potential Disease Modifying Treatment in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation
NCT06647498 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Texas: Dallas
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A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-1)
NCT05511363 ·
Phase: Phase 3 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· Texas: Flower Mound, Frisco, Houston
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A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-2)
NCT06126224 ·
Phase: Phase 3 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· Texas: Cypress, Houston, Katy, Red Oak
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A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down Syndrome (ABATE Study)
NCT05462106 ·
Phase: Phase 1, Phase 2 ·
Ages: 35 Years to 85 Years ·
Sex: All (male and female)
· Texas: San Antonio
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A Study to Assess the Efficacy and Safety of ITI-1284 in the Treatment of Agitation Associated With Alzheimer's Dementia
NCT06651567 ·
Phase: Phase 2 ·
Ages: 55 Years and older ·
Sex: All (male and female)
· Texas: San Antonio
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A Study to Assess the Efficacy and Safety of ITI-1284 in the Treatment of Psychosis Associated With Alzheimer's Disease
NCT06540833 ·
Phase: Phase 2 ·
Ages: 55 Years and older ·
Sex: All (male and female)
· Texas: Cypress, San Antonio
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A Study to Assess the Efficacy and Safety of ML-007C-MA for the Treatment of Alzheimer's Disease Psychosis
NCT06887192 ·
Phase: Phase 2 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· Texas: Austin, McKinney, Sugarland
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A Study to Assess the Safety and Effects of ABBV-1758 Following Subcutaneous or Intravenous Injections in Participants With Alzheimer's Disease
NCT07599670 ·
Phase: Phase 1, Phase 2 ·
Ages: 50 Years to 90 Years ·
Sex: All (male and female)
· Texas: Dallas
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A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)
NCT06585787 ·
Phase: Phase 3 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· Texas: Austin, Dallas, DeSoto, El Paso
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A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease
NCT06976216 ·
Phase: Phase 3 ·
Ages: 60 Years to 85 Years ·
Sex: All (male and female)
· Texas: Beaumont
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A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (MINDSET 2)
NCT06976203 ·
Phase: Phase 3 ·
Ages: 60 Years to 85 Years ·
Sex: All (male and female)
· Texas: Dallas, Round Rock
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A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)
NCT06937229 ·
Phase: Phase 3 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· Texas: Carrollton, Cypress, El Paso, Mesquite
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ACP-204 in Adults With Alzheimer's Disease Psychosis
NCT06159673 ·
Phase: Phase 2, Phase 3 ·
Ages: 55 Years to 95 Years ·
Sex: All (male and female)
· Texas: Cypress, Houston, Pasadena, Stafford
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Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant
NCT06563895 ·
Phase: Phase 3 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Texas: Austin, Dallas
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Advancing Alzheimer's Care: Home-based tDCS for Affective Symptoms
NCT06801639 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 60 Years to 85 Years ·
Sex: All (male and female)
· Texas: San Antonio
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Clinical Trial on Agitation in Alzheimer's Dementia
NCT05543681 ·
Phase: Phase 2 ·
Ages: 60 Years and older ·
Sex: All (male and female)
· Texas: Austin, Dallas
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Closed-Loop Brain Stimulation as a Potential Intervention for Cognitive Decline
NCT05907343 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 90 Years ·
Sex: All (male and female)
· Texas: Austin
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Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia
NCT05741853 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 40 Years and older ·
Sex: All (male and female)
· Texas: Austin
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Development of a Database to Investigate Digital and Blood-Based Biomarkers and Their Relationship to Tau and Amyloid PET Imaging in Older Participants Who Are Cognitively Normal (CN), Have Mild Cognitive Impairment (MCI), or Have Mild-to-Moderate AD Dementia
NCT06584357 ·
Phase: Not specified ·
Ages: 60 Years to 90 Years ·
Sex: All (male and female)
· Texas: Beaumont, Houston
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Educational Support Group Program for Bilingual and Spanish-speaking Carepartners and People With Progressive Aphasia
NCT06511752 ·
Phase: Early Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Texas: Austin
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Enhancing Sleep Quality for Nursing Home Residents With Dementia - R33 Phase
NCT05820919 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 50 Years and older ·
Sex: All (male and female)
· Texas: San Marcos
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Epidemiology and Biomarker Study in Alzheimer's Disease
NCT07142954 ·
Phase: Phase 3 ·
Ages: 55 Years to 75 Years ·
Sex: All (male and female)
· Texas: Houston
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ExAblate Blood-Brain Barrier (BBB) Disruption for the Treatment of Alzheimer's Disease
NCT03671889 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 50 Years to 85 Years ·
Sex: All (male and female)
· Texas: Dallas
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Glutathione, Brain Metabolism and Inflammation in Alzheimer's Disease
NCT04740580 ·
Phase: Early Phase 1 ·
Ages: 55 Years to 85 Years ·
Sex: All (male and female)
· Texas: Houston
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Interleukine-2 (IL-2) Plus Semaglutide in Alzheimer's Disease
NCT07651319 ·
Phase: Phase 1, Phase 2 ·
Ages: 50 Years to 86 Years ·
Sex: All (male and female)
· Texas: Houston
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Late Onset Alzheimer's Disease
NCT05010603 ·
Phase: Not specified ·
Ages: 55 Years and older ·
Sex: All (male and female)
· Texas: Dallas
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Masupirdine for the Treatment of Agitation in Dementia of the Alzheimer's Type
NCT05397639 ·
Phase: Phase 3 ·
Ages: 50 Years to 90 Years ·
Sex: All (male and female)
· Texas: Beaumont, Fort Worth, Houston
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NON-INVASIVE BRAIN STIMULATION FOR MEMORY LOSS IN EARLY ALZHEIMER'S DISEASE
NCT07667478 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· Texas: Houston
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Nighttime Agitation and Restless Legs Syndrome in People With Alzheimer's Disease
NCT03082755 ·
Phase: Phase 4 ·
Ages: 55 Years and older ·
Sex: All (male and female)
· Texas: Austin
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Novel Brain Stimulation Treatment for Neuropsychiatric Symptoms in Alzheimer's Disease
NCT06835283 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 65 Years to 85 Years ·
Sex: All (male and female)
· Texas: Houston
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Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)
NCT05980949 ·
Phase: Phase 3 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· Texas: Cypress, DeSoto, El Paso, Flower Mound
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Open-label Extension Study in Participants With Early Alzheimer's Disease
NCT07105709 ·
Phase: Phase 2 ·
Ages: 50 Years to 85 Years ·
Sex: All (male and female)
· Texas: Houston
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Paper-Based and Smartphone-Based Memory Supports
NCT06444841 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 50 Years and older ·
Sex: All (male and female)
· Texas: Austin, Temple, Waco
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Remotely-supervised Neuromodulation in PPA
NCT07260253 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 40 Years and older ·
Sex: All (male and female)
· Texas: Austin
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Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies
NCT07177352 ·
Phase: Phase 3 ·
Ages: 50 Years to 90 Years ·
Sex: All (male and female)
· Texas: Beaumont, Brownsville, Dallas, Edinburg
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Selective PET Imaging of Astrocytes and Microglia in Alzheimer's Disease
NCT05582200 ·
Phase: Not specified ·
Ages: 18 Years to 90 Years ·
Sex: All (male and female)
· Texas: Houston
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Smartphone-based Cognitive Emotion Regulation Training for Unpaid Primary Caregivers of Persons With Alzheimer's Disease
NCT05949047 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Texas: Houston
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Stem Cell Therapy for Early Alzheimer's Disease
NCT06775964 ·
Phase: Phase 1, Phase 2 ·
Ages: 60 Years to 80 Years ·
Sex: All (male and female)
· Texas: Houston
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Study of LHP588 in Subjects With P. Gingivalis-Positive Alzheimer's Disease
NCT06847321 ·
Phase: Phase 2 ·
Ages: 55 Years to 80 Years ·
Sex: All (male and female)
· Texas: Dallas
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Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986368, for the Treatment of Agitation in Participants With Alzheimer's Disease
NCT06808984 ·
Phase: Phase 2 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· Texas: Austin, Cypress, El Paso, Flower Mound
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Trial-Ready Cohort-Down Syndrome (TRC-DS)
NCT04165109 ·
Phase: Not specified ·
Ages: 25 Years to 55 Years ·
Sex: All (male and female)
· Texas: San Antonio
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[18F]PI-2620 Phase 3 Histopathological Study
NCT05641688 ·
Phase: Phase 3 ·
Ages: 50 Years and older ·
Sex: All (male and female)
· Texas: Dallas, Kerrville, Round Rock
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δ in Dementia Clinical Trials
NCT05592678 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 65 Years to 100 Years ·
Sex: All (male and female)
· Texas: San Antonio