-
A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease
NCT06283966 ·
Phase: Phase 3 ·
Ages: 40 Years to 80 Years ·
Sex: All (male and female)
· Pennsylvania: Camp Hill, DuBois, Exton, Philadelphia
-
A Study of 24 to 52 Weeks Treatment to Evaluate The Efficacy And Safety of Galvokimig in Study Participants With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD) With Chronic Bronchitis
NCT07725939 ·
Phase: Phase 2 ·
Ages: 40 Years to 80 Years ·
Sex: All (male and female)
· Pennsylvania: DuBois
-
A Study of WIN378 in Participants With Moderate to Severe COPD (Sirius)
NCT07646587 ·
Phase: Phase 2 ·
Ages: 40 Years to 80 Years ·
Sex: All (male and female)
· Pennsylvania: DuBois
-
A Study to Investigate Airway Inflammation With Dupilumab Subcutaneously in Participants Aged ≥40 to ≤85 Years With Chronic Obstructive Pulmonary Disease.
NCT07053423 ·
Phase: Phase 4 ·
Ages: 40 Years to 85 Years ·
Sex: All (male and female)
· Pennsylvania: DuBois
-
A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease
NCT07082738 ·
Phase: Phase 2 ·
Ages: 40 Years and older ·
Sex: All (male and female)
· Pennsylvania: Camp Hill, DuBois, Philadelphia, Pittsburgh
-
A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00006)
NCT06883305 ·
Phase: Phase 3 ·
Ages: 40 Years to 80 Years ·
Sex: All (male and female)
· Pennsylvania: DuBois, Philadelphia
-
A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00007)
NCT06878261 ·
Phase: Phase 3 ·
Ages: 40 Years to 80 Years ·
Sex: All (male and female)
· Pennsylvania: Horsham, Pittsburgh, Sayre
-
A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate to Severe Chronic Obstructive Pulmonary Disease
NCT07363694 ·
Phase: Phase 2, Phase 3 ·
Ages: 35 Years to 80 Years ·
Sex: All (male and female)
· Pennsylvania: DuBois
-
A Study to Test the Safety and Effects of Inhaled GDC-6988 in Participants With Muco-obstructive Disease
NCT06603246 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Pittsburgh
-
Acoustic Waveform Respiratory Evaluation
NCT06512064 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 8 Years to 70 Years ·
Sex: All (male and female)
· Pennsylvania: Pittsburgh
-
An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients With Severe Emphysema
NCT06035120 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 40 Years to 80 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia, Pittsburgh
-
Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3
NCT06891755 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 40 Years to 84 Years ·
Sex: All (male and female)
· Pennsylvania: DuBois, Philadelphia, Pittsburgh
-
COPD Exacerbation Follow Up
NCT07118306 ·
Phase: Not specified ·
Ages: 40 Years and older ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
-
Clinical Trial of Omalizumab for Allergen Sensitized and Exposed Individuals With COPD
NCT07059091 ·
Phase: Phase 2 ·
Ages: 40 Years and older ·
Sex: All (male and female)
· Pennsylvania: Philadelphia, Pittsburgh
-
Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening
NCT06122077 ·
Phase: Not specified ·
Ages: 50 Years and older ·
Sex: All (male and female)
· Pennsylvania: DuBois, Lancaster, Philadelphia, Sayre
-
Closed Loop Oxygen Control in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Nasal High Flow in the Hospital
NCT07222410 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 22 Years and older ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
-
Depemokimab as an Extended treatmeNt Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA-2)
NCT06961214 ·
Phase: Phase 3 ·
Ages: 40 Years to 80 Years ·
Sex: All (male and female)
· Pennsylvania: DuBois, Philadelphia
-
Effect of Ensifentrine on Sputum Markers of Inflammation in COPD
NCT05270525 ·
Phase: Phase 2 ·
Ages: 40 Years to 80 Years ·
Sex: All (male and female)
· Pennsylvania: Pittsburgh
-
Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD) Characterized by an Eosinophilic Phenotype
NCT07190209 ·
Phase: Phase 3 ·
Ages: 40 Years to 80 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia, Pittsburgh
-
Emphysema Research Registry and Biosample Repository
NCT00307281 ·
Phase: Not specified ·
Ages: 21 Years and older ·
Sex: All (male and female)
· Pennsylvania: Pittsburgh
-
Evaluating the Safety and Efficacy of dNerva Lung Denervation System in Patients With COPD
NCT07051707 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 40 Years to 80 Years ·
Sex: All (male and female)
· Pennsylvania: DuBois, Philadelphia, Pittsburgh
-
Feasibility of Semaglutide in Advanced Lung Disease
NCT05746039 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
-
Leveraging Lung Cancer Screening to Optimize Screening Outcomes and COPD Management: COPD in LCS Registry
NCT06974981 ·
Phase: Not specified ·
Ages: 50 Years to 80 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
-
Lung and Bone Marrow Transplantation for Lung and Bone Marrow Failure
NCT03500731 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 60 Years ·
Sex: All (male and female)
· Pennsylvania: Pittsburgh
-
Multi-Center Clean Air Randomized Controlled Trial in COPD
NCT06376994 ·
Phase: Phase 3 ·
Ages: 40 Years and older ·
Sex: All (male and female)
· Pennsylvania: West Reading
-
Relationship of Inflammation and Pulmonary Function to Fungal Translocation in HIV
NCT05502653 ·
Phase: Not specified ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female)
· Pennsylvania: Pittsburgh
-
SPIROMICS Study of Early COPD Progression (SOURCE)
NCT05033990 ·
Phase: Not specified ·
Ages: 30 Years to 55 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
-
STRIVE Post-Market Registry Study
NCT04302272 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Hershey, Philadelphia
-
Supporting Evidence-based Responses to Emotional Needs in Emphysema
NCT06600126 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
-
Temple Health Chest Initiative (THCI 2.0)
NCT06933758 ·
Phase: Not specified ·
Ages: 50 Years to 80 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
-
To Evaluate the Effect of EXPD-101/FXS7553 Compared With Placebo in Patients With COPD Over 52 Weeks of Treatment
NCT07684820 ·
Phase: Phase 2 ·
Ages: 40 Years to 85 Years ·
Sex: All (male and female)
· Pennsylvania: DuBois, Philadelphia
-
Trial Comparing the Safety and Efficacy of Two Different Oral VPV Doses With Placebo as Treatment for RV in Participants With COPD
NCT07610395 ·
Phase: Phase 2 ·
Ages: 40 Years to 85 Years ·
Sex: All (male and female)
· Pennsylvania: DuBois, Pittsburgh, Sayre
-
eValuating the Efficacy and Safety of InitiatinG depemokImab earLy therApy iN Chronic Obstructive Pulmonary Disorder (COPD) With Type 2 Inflammation
NCT07177339 ·
Phase: Phase 3 ·
Ages: 40 Years to 75 Years ·
Sex: All (male and female)
· Pennsylvania: DuBois, West Chester
-
myAirvo 3 (High Flow Nasal Therapy; HFNT) for COPD Patients in the Home
NCT05204888 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 30 Years and older ·
Sex: All (male and female)
· Pennsylvania: Bethlehem, DuBois, Philadelphia, Pittsburgh