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A Phase 3 Study of Tabelecleucel for Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure With Rituximab or Rituximab and Chemotherapy
NCT03394365 ·
Phase: Phase 3 ·
Ages: No age limits stated ·
Sex: All (male and female)
· Connecticut: New Haven
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A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)
NCT05489705 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Connecticut: Hartford
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A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF
NCT07761117 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Connecticut: New Haven
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A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
NCT06424288 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Connecticut: Bridgeport
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A Trial Comparing High-Flow Nasal Cannula Versus Noninvasive Ventilation on Reintubation and Post-Extubation Respiratory Failure in High-Risk Patients With Systolic Heart Failure
NCT06671015 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Connecticut: New Haven
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Alleviant ALLAY-HF Study
NCT05685303 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 40 Years and older ·
Sex: All (male and female)
· Connecticut: Hartford
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Assessment of CCM in HF With Higher Ejection Fraction
NCT05064709 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Connecticut: Danbury, Hartford
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Beta-blocker Discontinuation in Heart Failure With Preserved Ejection Fraction
NCT05174351 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 50 Years to 80 Years ·
Sex: All (male and female)
· Connecticut: Farmington
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CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis
NCT07207811 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Connecticut: New Haven
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Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure
NCT00762008 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Connecticut: Farmington
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Circulating Markers for Ischemic Heart Disease
NCT00762333 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Connecticut: Farmington
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Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis (POSIBIL6ESKD)
NCT05485961 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Connecticut: Bloomfield, Middlebury
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ELEVATE-HFpEF Clinical Study
NCT06678841 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 40 Years and older ·
Sex: All (male and female)
· Connecticut: Hartford
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Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment
NCT01790152 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· Connecticut: New Haven
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Ertugliflozin in Chronic Heart Failure
NCT04438213 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Connecticut: New Haven
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Exploring Water-free Sodium Storage
NCT06872645 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Connecticut: New Haven
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Implementation and Interaction of Clinician And Patient-facing Tools Aiming to Intensify Neurohormonal Medicines for Heart Failure
NCT06526988 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Connecticut: New Haven
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Integration of Telemedicine and Home-Based Cardiac Rehabilitation: Feasibility, Efficacy, and Adherence
NCT05972070 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Connecticut: Brookfield
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Left vs Left Randomized Clinical Trial
NCT05650658 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Connecticut: Hartford, New Haven
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Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
NCT07037459 ·
Phase: Phase 3 ·
Ages: 18 Years to 99 Years ·
Sex: All (male and female)
· Connecticut: Stamford
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Mechanisms of Diuretic Resistance in Heart Failure, Aim 1
NCT05323487 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Connecticut: New Haven
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Mechanisms of Diuretic Resistance in Heart Failure, Aim 2
NCT05753059 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Connecticut: New Haven
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Mechanisms of Diuretic Resistance in Heart Failure, Aim 3
NCT06209359 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Connecticut: New Haven
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Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin
NCT06677060 ·
Phase: Phase 3 ·
Ages: 40 Years and older ·
Sex: All (male and female)
· Connecticut: Bridgeport, Stamford, Waterbury
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Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
NCT00271180 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· Connecticut: Hartford, New Haven
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Promoting Palliative Care for People With Heart Failure
NCT06933875 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Connecticut: New Haven
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REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE
NCT06777368 ·
Phase: Not specified ·
Ages: 18 Years to 105 Years ·
Sex: All (male and female)
· Connecticut: Hartford, New Haven
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Real-Time Monitoring of Heart Failure Across the Yale New Haven Health System
NCT04237701 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Connecticut: New Haven
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Simulation Trial of Telemedical Support for Paramedics
NCT06441760 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 21 Years and older ·
Sex: All (male and female)
· Connecticut: New Haven
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Sodium-Glucose Cotransporter-2 Inhibitor for Patients With Acute Cardiorenal Syndrome
NCT07273838 ·
Phase: Phase 2 ·
Ages: 18 Years to 85 Years ·
Sex: All (male and female)
· Connecticut: New Haven
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Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
NCT06736574 ·
Phase: Phase 3 ·
Ages: 18 Years to 85 Years ·
Sex: All (male and female)
· Connecticut: Bridgeport, Hartford, New Haven
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The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C)
NCT05427370 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Connecticut: New Haven
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Unmitigated Aldosterone Signaling During Standard Clinical MRA Dosing
NCT07281014 ·
Phase: Phase 4 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Connecticut: New Haven