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A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)
NCT05489705 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Indiana: Indianapolis
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A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
NCT07567001 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Indiana: Hammond, Indianapolis
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A Study of EDG-15400 in Adults With Heart Failure With Preserved Ejection Fraction (EQUINOX-HFpEF)
NCT07795814 ·
Phase: Phase 2 ·
Ages: 30 Years to 84 Years ·
Sex: All (male and female)
· Indiana: Indianapolis
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A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients With Heart Failure (CONFIRMATION-HF)
NCT06024746 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Indiana: Merrillville
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A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
NCT06008197 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Indiana: Indianapolis, Merrillville
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A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients With Heart Failure Who Are Intolerant or Not Eligible for Treatment With Steroidal Mineralocorticoid Receptor Antagonists
NCT06033950 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Indiana: Merrillville
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A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF
NCT07761117 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Indiana: Indianapolis
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A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)
NCT06991257 ·
Phase: Phase 2 ·
Ages: 18 Years to 79 Years ·
Sex: All (male and female)
· Indiana: Fort Wayne, Richmond
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A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction
NCT07192952 ·
Phase: Phase 3 ·
Ages: Up to 18 Years ·
Sex: All (male and female)
· Indiana: Indianapolis
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A Study to Learn More About How Well Finerenone Works, How Safe it is, and How it Moves Into, Through, and Out of the Body Compared to Placebo When Taken With Standard Treatment in Children With Heart Failure and Left Ventricular Systolic Dysfunction
NCT07188805 ·
Phase: Phase 3 ·
Ages: 6 Months to 17 Years ·
Sex: All (male and female)
· Indiana: Indianapolis
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A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
NCT06935370 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Indiana: Elkhart, Indianapolis, Munster, Richmond
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A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
NCT06424288 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Indiana: Elkhart, Indianapolis, Merrillville, Munster
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Alleviant ALLAY-HF Study
NCT05685303 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 40 Years and older ·
Sex: All (male and female)
· Indiana: Indianapolis
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Assessment of CCM in HF With Higher Ejection Fraction
NCT05064709 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Indiana: Indianapolis
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CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis
NCT07207811 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Indiana: Indianapolis
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Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis (POSIBIL6ESKD)
NCT05485961 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Indiana: Fort Wayne, Mishawaka
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Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects Having HFpEF
NCT04592445 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 40 Years and older ·
Sex: All (male and female)
· Indiana: Indianapolis
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HF2 Registry - Hemodynamic Frontiers in Heart Failure Registry
NCT06425848 ·
Phase: Not specified ·
Ages: 18 Years to 100 Years ·
Sex: All (male and female)
· Indiana: Bloomington
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Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure
NCT06310031 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 100 Years ·
Sex: All (male and female)
· Indiana: Indianapolis
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LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2
NCT07288398 ·
Phase: Phase 3 ·
Ages: 18 Years to 85 Years ·
Sex: All (male and female)
· Indiana: Indianapolis
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Left vs Left Randomized Clinical Trial
NCT05650658 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Indiana: Indianapolis
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Leg Heat Therapy in Heart Failure With Preserved Ejection Fraction
NCT06388226 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Indiana: Indianapolis
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Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
NCT07037459 ·
Phase: Phase 3 ·
Ages: 18 Years to 99 Years ·
Sex: All (male and female)
· Indiana: Elkhart, Indianapolis, Munster, Richmond
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PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III
NCT05934487 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Indiana: Indianapolis
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Palliative Care for People With HF
NCT07356843 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Indiana: Indianapolis
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Pediatric Cardiomyopathy Mutation Analysis
NCT02432092 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· Indiana: Indianapolis
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Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
NCT04278404 ·
Phase: Not specified ·
Ages: 0 Years to 20 Years ·
Sex: All (male and female)
· Indiana: Indianapolis
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Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin
NCT06677060 ·
Phase: Phase 3 ·
Ages: 40 Years and older ·
Sex: All (male and female)
· Indiana: Indianapolis, Munster, Richmond, South Bend
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Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
NCT00271180 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· Indiana: Evansville, Indianapolis
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REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE
NCT06777368 ·
Phase: Not specified ·
Ages: 18 Years to 105 Years ·
Sex: All (male and female)
· Indiana: Fort Wayne, Indianapolis
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Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure
NCT07069738 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Indiana: Indianapolis
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Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction
NCT02901184 ·
Phase: Phase 3 ·
Ages: 50 Years to 99 Years ·
Sex: All (male and female)
· Indiana: Indianapolis
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Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
NCT06736574 ·
Phase: Phase 3 ·
Ages: 18 Years to 85 Years ·
Sex: All (male and female)
· Indiana: Munster, Newburgh, Richmond
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Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function
NCT06307652 ·
Phase: Phase 3 ·
Ages: 18 Years to 130 Years ·
Sex: All (male and female)
· Indiana: Elkhart, Evansville, Hammond, Indianapolis
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TRIcvalve biCAVal Valve System for Severe Tricuspid Regurgitation (TRICAV-I)
NCT06137807 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Indiana: Indianapolis
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The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR
NCT03142152 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Indiana: Indianapolis
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Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
NCT06526195 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Indiana: Indianapolis