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A Multi-center, National, Open-label, Prospective Study to Evaluate the Performance of the V-Lap™ System
NCT06147336 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 22 Years to 88 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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A Phase 3 Study of Tabelecleucel for Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure With Rituximab or Rituximab and Chemotherapy
NCT03394365 ·
Phase: Phase 3 ·
Ages: No age limits stated ·
Sex: All (male and female)
· Massachusetts: Boston
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A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)
NCT05489705 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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A SkeleTal Muscle Recovery Intervention With Dietary Protein in Heart Failure
NCT05627440 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 100 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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A Study of Mavorixafor in Participants With Congenital and Acquired Primary Autoimmune and Idiopathic Chronic Neutropenic Disorders Who Are Experiencing Recurrent and/or Serious Infections
NCT06056297 ·
Phase: Phase 3 ·
Ages: 12 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
NCT06008197 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF
NCT07761117 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston, New Bedford, Worcester
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A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction
NCT07192952 ·
Phase: Phase 3 ·
Ages: Up to 18 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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A Study to Learn More About How Well Finerenone Works, How Safe it is, and How it Moves Into, Through, and Out of the Body Compared to Placebo When Taken With Standard Treatment in Children With Heart Failure and Left Ventricular Systolic Dysfunction
NCT07188805 ·
Phase: Phase 3 ·
Ages: 6 Months to 17 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEF
NCT06793371 ·
Phase: Phase 2 ·
Ages: 40 Years to 85 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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ANDREAS Registry (Assessment of Novel Drug-coated Balloon Revascularization: Effectiveness, Angiographic Outcomes, and Safety)
NCT07559903 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Alleviant ALLAY-HF Study
NCT05685303 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 40 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston, Brighton
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Alleviant ALLAY-HFrEF Study
NCT06812533 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Assessment of CCM in HF With Higher Ejection Fraction
NCT05064709 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Biomechanical Precision Medicine Registry for Patients With and Without Heart Failure
NCT03480633 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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CCM OPEN HF Registry
NCT07112924 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis
NCT07207811 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Cardiac Resynchronization Therapy Delivery Guided Non-Invasive Electrical and Venous Anatomy Assessment
NCT05327062 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Cardiogenic Shock Working Group Registry
NCT04682483 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Care Transitions App for Patients With Multiple Chronic Conditions
NCT06051058 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 55 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Changes in Skeletal Muscle Thickness in Patients With Acute Heart Failure
NCT06253104 ·
Phase: Not specified ·
Ages: 18 Years to 100 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis (POSIBIL6ESKD)
NCT05485961 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Diffusion MRI in Heart Failure
NCT02973633 ·
Phase: Early Phase 1 ·
Ages: 18 Years to 85 Years ·
Sex: All (male and female)
· Massachusetts: Charlestown
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ELEVATE-HFpEF Clinical Study
NCT06678841 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 40 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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EXercise and Activin Inhibition to Modulate InflammatioN Effects on Heart Failure and Cognition (EXAMINE-HFC)
NCT07202000 ·
Phase: Phase 2 ·
Ages: 40 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment
NCT01790152 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· Massachusetts: Boston
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Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
NCT05714085 ·
Phase: Phase 2, Phase 3 ·
Ages: 29 Days to 17 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Feasibility and Efficacy Study of the CardioPulmonary Management (CPM) System in Patients With Chronic Heart Failure
NCT05650541 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Springfield
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HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets
NCT05873634 ·
Phase: Not specified ·
Ages: 30 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Home Hospital for Suddenly Ill Adults
NCT03524222 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Identification of Genomic Predictors of Adverse Events After Cardiac Surgery
NCT01258231 ·
Phase: Not specified ·
Ages: 20 Years to 90 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Imaging Histone Deacetylase in the Heart
NCT03549559 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 85 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure
NCT06310031 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 100 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2
NCT07288398 ·
Phase: Phase 3 ·
Ages: 18 Years to 85 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Left vs Left Randomized Clinical Trial
NCT05650658 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Manual Versus AI-Assisted Clinical Trial Screening Using Large-Language Models
NCT06588452 ·
Phase: Not specified ·
Ages: 18 Years to 90 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Mindful Steps 2.0: Promoting Physical Activity in Patients With COPD and HF
NCT05934565 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 40 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction
NCT06517186 ·
Phase: Not specified ·
Ages: 30 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Non-interventional Study of Seroprevalence of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV9) and the Progression of Disease in Patients With Plakophilin 2 (PKP2)-Associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)
NCT06311708 ·
Phase: Not specified ·
Ages: 14 Years to 65 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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OPtimal Adult Heart Transplant Immunosuppression With MicroRNA Levels
NCT06939751 ·
Phase: Not specified ·
Ages: 18 Years to 99 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Open-label, Dose Escalation Study of Safety and Preliminary Efficacy of TN-401 in Adults With PKP2 Mutation-associated ARVC
NCT06228924 ·
Phase: Phase 1 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III
NCT05934487 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
NCT04278404 ·
Phase: Not specified ·
Ages: 0 Years to 20 Years ·
Sex: All (male and female)
· Massachusetts: Boston, Lexington
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Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin
NCT06677060 ·
Phase: Phase 3 ·
Ages: 40 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston, New Bedford, Roslindale
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Prevalence and Prediction of ATTR in Ambulatory Patients With HFpEF
NCT05577819 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 65 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
NCT00271180 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· Massachusetts: Boston
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Promoting Well-being and Health in Heart Failure
NCT04829617 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Pulmonary Artery Catheter in Cardiogenic Shock Trial
NCT05485376 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 90 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Purinergic Signaling and the Postmenopausal Heart
NCT06015776 ·
Phase: Not specified ·
Ages: 30 Years to 88 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE
NCT06777368 ·
Phase: Not specified ·
Ages: 18 Years to 105 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Retinal Fundus Imaging and OCT Imaging for Ocular Detection of ATTR-CM
NCT07690436 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure
NCT07069738 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Fall River
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Salivary Extracellular Vesicle Associated lncRNAs in Heart Failure (SEAL-HF)
NCT06169540 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Simulation Trial of Telemedical Support for Paramedics
NCT06441760 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 21 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease
NCT06217302 ·
Phase: Phase 3 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction
NCT02901184 ·
Phase: Phase 3 ·
Ages: 50 Years to 99 Years ·
Sex: All (male and female)
· Massachusetts: Boston, Haverhill, Natick, Newton
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Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
NCT06736574 ·
Phase: Phase 3 ·
Ages: 18 Years to 85 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function
NCT06307652 ·
Phase: Phase 3 ·
Ages: 18 Years to 130 Years ·
Sex: All (male and female)
· Massachusetts: Boston, Fall River, Worcester
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TRIcvalve biCAVal Valve System for Severe Tricuspid Regurgitation (TRICAV-I)
NCT06137807 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston, Burlington
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Targeted Artificial Intelligence Language mOdel Recommendations for Heart Failure (TAILOR-HF)
NCT07337577 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 85 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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The CARDIOPROTECT Trial
NCT07654426 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR
NCT03142152 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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The STOP-MED CTRCD Trial
NCT06183437 ·
Phase: Phase 4 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
NCT06526195 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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US Benchmarking Clinical Study
NCT07215715 ·
Phase: Not specified ·
Ages: 60 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Congestive Heart Failure Receiving Therapy for Breast Cancer
NCT02610426 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· Massachusetts: Boston