Phase 2 Major Depressive Disorder (MDD) trials recruiting now

All Major Depressive Disorder (MDD) trials, every phase

Other phases for Major Depressive Disorder (MDD)

Phase 2 Major Depressive Disorder (MDD) trials

• A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
  NCT07621237 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · 25 locations
• A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
  NCT07610473 · Phase: Phase 2 · Ages: 18 Years to 75 Years · Sex: All (male and female) · 23 locations
• A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
  NCT07300969 · Phase: Phase 2 · Ages: 18 Years to 75 Years · Sex: All (male and female) · 43 locations
• A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
  NCT07065240 · Phase: Phase 2 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 61 locations
• A Study to Evaluate the Efficacy, Safety, and Pharmacokinetic Characteristics of (R)-Ketamine Hydrochloride Nasal Spray in Patients With Depression and Acute Suicidal Ideation or Behavior
  NCT07193901 · Phase: Phase 2 · Ages: 18 Years to 64 Years · Sex: All (male and female) · 8 locations
• ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
  NCT07284667 · Phase: Phase 2 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 26 locations
• Cannabidiol Oil for Treatment-Resistant Major Depression
  NCT07696871 · Phase: Phase 1, Phase 2 · Ages: 18 Years to 69 Years · Sex: All (male and female) · 1 location
• Dextromethorphan-Bupropion on Striatal Activity in Adults With Major Depressive Disorder
  NCT07523048 · Phase: Phase 2 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Double-blind, Placebo-controlled Study in Adults With Major Depressive Disorder
  NCT07226661 · Phase: Phase 2 · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• Inhaled DMT for Major Depressive Disorder
  NCT07562191 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · 5 locations
• Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT)
  NCT07569198 · Phase: Phase 2 · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• Orexin Antagonism for Suicide Risk: A Proof-of-Concept Clinical Trial
  NCT06854224 · Phase: Phase 2 · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• Psilocybin Therapy for Psychological Distress in Palliative Patients
  NCT06782724 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · 8 locations
• Sertraline Combined With Multi-Strain Probiotics for Adolescent Depression
  NCT07645157 · Phase: Phase 2 · Ages: 12 Years to 18 Years · Sex: All (male and female) · 1 location
• Understanding and Treating Suicidal Ideation With Ketamine
  NCT06891300 · Phase: Phase 2, Phase 3 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location

Common questions

What does Phase 2 mean?

See how clinical trials work.

Is this list complete?

No. For the full record, search ClinicalTrials.gov.