Clinical trials recruiting for Persistent Atrial Fibrillation

Phase breakdown

Drugs and treatments being studied

Where trials are recruiting (top US states)

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Recruiting trials

• A Prospective Clinical Study to Evaluate the Safety and Effectiveness of Pulmonary Vein Isolation Plus Box Isolation of Fibrotic Areas With the Globe® Pulsed Field System for Treating Patients With Symptomatic Paroxysmal or Persistent Atrial Fibrillation
  NCT06973031 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 80 Years · Sex: All (male and female) · 1 location
• A Study Assessing Arrhythmia Mapping With a Multi-Electrode Mapping Catheter
  NCT07116525 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 5 locations
• ARIADNE Clinical Trial
  NCT06747091 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 80 Years · Sex: All (male and female) · 3 locations
• AV Junction Ablation or Optimal Medical Treatment in PatiEnts With Cardiac Resynchronization Therapy and Permanent Atrial Fibrillation
  NCT05776797 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 85 Years · Sex: All (male and female) · 9 locations
• BaLloon-based PFA Ablation poST Approval Outcomes for PAF and PersAF
  NCT07181590 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 22 locations
• Comprehensive LEFt Atrial Appendage Occlusion With Rhythm Restoration
  NCT07523620 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 16 locations
• Conquer-AF Protocol for Redo Ablation Procedures in Recurrent Paroxysmal and Persistent Atrial Fibrillation Using the Sphere-9 Catheter and Affera Ablation System (Conquer-AF)
  NCT07298473 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 30 locations
• Convergent Ablation Plus Left Atrial Appendage Isolation for the Treatment of Persistent Atrial Fibrillation
  NCT06165510 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 80 Years · Sex: All (male and female) · 1 location
• EfFect of Ablation of Persistent AtriaL Fibrillation on COgNitive Function in Individuals With Mild Cognitive Impairment
  NCT05790707 · Phase: Not applicable (e.g. observational or device study) · Ages: 60 Years to 80 Years · Sex: All (male and female) · 8 locations
• Endocardial Mapping With the CoreMap EP Mapping System
  NCT06529978 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 80 Years · Sex: All (male and female) · 4 locations
• Evaluation of Novel Waveforms Delivered Using the FARAPULSE™ PFA System
  NCT07444320 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 4 locations
• Evaluation of Two Different Regimens of the Antiarrhythmic Drug Amiodarone to Maintain Normal Sinus Rhythm After Electrical Cardioversion in Patients With Persistent Atrial Fibrillation
  NCT07273994 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Evaluation of the Efficacy of Pulmonary Vein Isolation by Pulsed-field Ablation in Persistent Atrial Fibrillation: a Multicenter Study With Follow-up by Implantable Cardiac Monitor
  NCT06985901 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Evaluation of the FARAFLEX Mapping and Pulsed Field Ablation System in Subjects With Atrial Fibrillation
  NCT07575269 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 9 locations
• FIH Study of PFLotus in Persistent Atrial Fibrillation
  NCT07301190 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 75 Years · Sex: All (male and female) · 1 location
• Feasibility Study of the FARAFLEX Mapping and PFA System
  NCT06510556 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 4 locations
• Hybrid Ablation of Atrial Fibrillation in Heart Failure
  NCT05411614 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 14 locations
• Investigation of Cardioversion Versus Therapeutic Ablation for Persistent AF (ORBICA-AF)
  NCT06096246 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 85 Years · Sex: All (male and female) · 1 location
• Medtronic Terminate AF Study
  NCT03546374 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 15 locations
• Observational Study to Examine the Procedural and Outcomes of AF Ablation Assisted by STAR Apollo™ Mapping System
  NCT05826665 · Phase: Not specified · Ages: 18 Years to 80 Years · Sex: All (male and female) · 4 locations
• Optimized Ablation of the Posterior Wall in Persistent Atrial Fibrillation
  NCT07122336 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 80 Years · Sex: All (male and female) · 1 location
• PREACTIVE: Preconditioning Exercise Intervention to Improve Symptoms and Quality of Life in Comorbid Atrial Fibrillation and HFpEF
  NCT07324772 · Phase: Not applicable (e.g. observational or device study) · Ages: 60 Years to 99 Years · Sex: All (male and female) · 2 locations
• PVI Alone Versus PVI Plus PWI and SVCI With PFA
  NCT07405359 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• PVI Alone vs PVI and Linear Ablation for Persistent Atrial Fibrillation (PROMPT AF II)
  NCT07106970 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 80 Years · Sex: All (male and female) · 1 location
• Pulmonary Vein Isolation Alone or in Combination With Substrate Modulation After Electric Cardioversion Failure
  NCT05264831 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 80 Years · Sex: All (male and female) · 13 locations
• Pulsed Field Ablation vs. Cryoballoon Ablation in Patients With Persistent Atrial Fibrillation
  NCT07064616 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 85 Years · Sex: All (male and female) · 1 location
• REPRESENT-PF Registry
  NCT07535268 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• Real-world Experience of Catheter Ablation for the Treatment of Arrhythmias
  NCT04088071 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 70 locations
• Repeat Ablation of Persistent Atrial Fibrillation, Including Mitral Isthmus Catheter Ablation, With the FARAPULSE Pulsed Field Ablation System
  NCT06735534 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 41 locations
• Study on the Prevention of Atrial Fibrillation Recurrence After Ablation by Qidong Yixin Granule
  NCT07508618 · Phase: Phase 4 · Ages: 18 Years to 80 Years · Sex: All (male and female) · 5 locations
• VEin of MArshall Ethanolization Vs Extended Pulmonary Vein PULSEd Field Ablation After Failed PVI for Persistent AF
  NCT06383975 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location

Related conditions

Trials recruiting for Persistent Atrial Fibrillation often also study these conditions. Each links to its own recruiting-trial list.

Common questions

Are these trials free to join?

Study-related care in a clinical trial is usually provided at no cost to participants, and some trials reimburse travel. Costs vary by study - the trial team will explain what is and is not covered. Confirm this directly with them.

How do I know if I am eligible for Persistent Atrial Fibrillation trials?

Each trial lists inclusion and exclusion criteria. The screener above checks stated age and sex only. The full eligibility (your medical history, current medications, test results) is assessed by the study team. Open any trial to read its criteria, then contact the site.

Is this list complete?

No. For the full list, search ClinicalTrials.gov.