Clinical trials recruiting for Rectal Adenocarcinoma

Phase breakdown

Drugs and treatments being studied

Where trials are recruiting (top US states)

Top cities

Self-screener

Recruiting trials

• A Global, Integrated, Personalized, Stage-related, Multimodal Therapeutic Approach for Rectal Adenocarcinoma Based on Organ Sparing and Mininvasivity
  NCT06952101 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• A Study of Tucatinib and Trastuzumab in People With Rectal Cancer
  NCT05672524 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · 7 locations
• Active Surveillance and Chemotherapy Before Surgery in Treating Participants With Stage II-III Rectal Cancer
  NCT03594630 · Phase: Early Phase 1 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Asian Watch-and-Wait Database (AWWD)
  NCT06631443 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Dose Escalated Radiotherapy for Rectal Cancers Using MR-guided Radiotherapy
  NCT06854679 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Establishing a ctDNA Biomarker to Improve Organ Preserving Strategies in Patients With Rectal Cancer
  NCT05081024 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• Evaluating Novel Therapies in ctDNA Positive GI Cancers
  NCT05482516 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 6 locations
• FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery
  NCT06780787 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Factors Affecting the Results of Treatment of Patients With Colorectal Cancer
  NCT06050447 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Family Communications After Genetic Testing
  NCT07143487 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 299 locations
• MRI-Guided Adaptive Radiation Therapy for Organ Preservation in Rectal Cancer
  NCT04808323 · Phase: Phase 1 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Monitoring Treatment Response With On-board DWI During Neo-adjuvant Chemo-radiation for Rectal Cancer Using Magnetic Resonance-guided-radiotherapy Systems
  NCT03961776 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• Nordic ORgan Preservation Pilot Approach Nonrandomised Single-Arm Trial for Non-Operative Management of Rectal Cancer
  NCT06328361 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 13 locations
• ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
  NCT05059444 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 57 locations
• Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
  NCT07292298 · Phase: Phase 2 · Ages: 18 Years to 100 Years · Sex: All (male and female) · 3 locations
• ProLARS Trial: Prospective Longitudinal Follow-up of Low Anterior Resection Syndrome (LARS) and COREFO Score After Rectum Surgery in Patients Undergoing Upfront Surgery or Different Neo-adjuvant Treatment Regimens
  NCT07339904 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• SCRT + Chemo Targeted Immuno-neoadjuvant Therapy for High-risk pMMR/MSS RC
  NCT07549399 · Phase: Phase 3 · Ages: 18 Years to 75 Years · Sex: All (male and female) · 1 location
• SCRT Followed by CAPOX + Bev ± PD-1 Inhibitor for TNT in LARC
  NCT07198165 · Phase: Phase 2 · Ages: 18 Years to 75 Years · Sex: All (male and female) · 1 location
• Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer
  NCT04703101 · Phase: Phase 1 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid Tumors
  NCT04165772 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · 10 locations
• The Efficacy and Safety of Short-course Radiation Combined With Adebrelimab and CAPEOX Neo-adjuvant Therapy for Organ-retention in Patients With MSS/pMMR Ultra Low Rectal Adenocarcinoma
  NCT06266832 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Trial Utilizing Metronidazole to Optimize the Microbiome of Rectal Adenocarcinoma Undergoing Neoadjuvant Therapy
  NCT06569368 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Upfront Trastuzumab-Deruxtecan Plus Capecitabine and Bevacizumab for Patients With HER-2 Positive Metastatic Colorectal Cancer.
  NCT07407465 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · 28 locations

Related conditions

Trials recruiting for Rectal Adenocarcinoma often also study these conditions. Each links to its own recruiting-trial list.

Common questions

Are these trials free to join?

Study-related care in a clinical trial is usually provided at no cost to participants, and some trials reimburse travel. Costs vary by study - the trial team will explain what is and is not covered. Confirm this directly with them.

How do I know if I am eligible for Rectal Adenocarcinoma trials?

Each trial lists inclusion and exclusion criteria. The screener above checks stated age and sex only. The full eligibility (your medical history, current medications, test results) is assessed by the study team. Open any trial to read its criteria, then contact the site.

Is this list complete?

No. For the full list, search ClinicalTrials.gov.