-
52-week Open Label Safety-Tolerability Study
NCT07369154 ·
Phase: Phase 3 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· California: Anaheim, Cerritos, Culver City, San Diego
-
A Long-Term Open-Label Study of ML-007C-MA in Adults With Schizophrenia
NCT07459647 ·
Phase: Phase 2 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· California: Bellflower, Cerritos, Culver City, Garden Grove
-
A Novel Peer-Delivered Recovery-Focused Suicide Prevention Intervention for Veterans With Serious Mental Illness
NCT05537376 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· California: San Diego
-
A Study of Brenipatide in Adult Participants With Schizophrenia
NCT07410507 ·
Phase: Phase 2 ·
Ages: 18 Years to 55 Years ·
Sex: All (male and female)
· California: Bellflower, Garden Grove, Montclair, Stanford
-
A Study of LTX-001 In Adult Participants With Acute Exacerbation of Schizophrenia
NCT07734493 ·
Phase: Phase 1 ·
Ages: 18 Years to 55 Years ·
Sex: All (male and female)
· California: Los Alamitos
-
A Study of the Feasibility, Safety and Tolerability of Aticaprant as Adjunctive Treatment in Participants With Schizophrenia
NCT07615426 ·
Phase: Phase 1 ·
Ages: 18 Years to 55 Years ·
Sex: All (male and female)
· California: Garden Grove
-
A Study to Assess Adverse Events, Change in Disease Activity, and How Oral Emraclidine Moves Through the Body in Adult Participants With Schizophrenia
NCT07145918 ·
Phase: Phase 2 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· California: Glendale, Los Alamitos
-
A Study to Assess the Efficacy and Safety of ITI-1284 in the Treatment of Psychosis Associated With Alzheimer's Disease
NCT06540833 ·
Phase: Phase 2 ·
Ages: 55 Years and older ·
Sex: All (male and female)
· California: Anaheim, Los Alamitos, Newport Beach, Orange
-
A Study to Assess the Efficacy and Safety of ML-007C-MA for the Treatment of Alzheimer's Disease Psychosis
NCT06887192 ·
Phase: Phase 2 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· California: Anaheim, Long Beach, Murrieta, Orange
-
A Study to Evaluate KYN-5356 in Adults With Cognitive Impairment Associated With Schizophrenia
NCT07191483 ·
Phase: Phase 2 ·
Ages: 18 Years to 55 Years ·
Sex: All (male and female)
· California: Cerritos, Lemon Grove, Los Alamitos
-
A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)
NCT06585787 ·
Phase: Phase 3 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· California: Anaheim, Chino, Long Beach, Los Angeles
-
A Study to Evaluate Safety and Efficacy of KarXT + KarX-EC as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-5)
NCT06947941 ·
Phase: Phase 3 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· California: Chino
-
A Study to Evaluate the Effect of KarXT on Urological Safety
NCT07221877 ·
Phase: Phase 4 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· California: Bellflower, Garden Grove, Orange
-
A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor
NCT07105111 ·
Phase: Phase 4 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· California: Chino, Fountain Valley, Fresno, Long Beach
-
A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Schizophrenia in Adolescents (EMERGENT TEEN)
NCT07288567 ·
Phase: Phase 3 ·
Ages: 13 Years to 17 Years ·
Sex: All (male and female)
· California: Anaheim, Chino, Culver City, San Francisco
-
A Study to Evaluate the Long-term Safety and Tolerability of KarXT and KarX-EC for the Treatment of Schizophrenia and Autism-Related Irritability in Adolescents, Respectively
NCT07424404 ·
Phase: Phase 3 ·
Ages: 5 Years to 17 Years ·
Sex: All (male and female)
· California: Anaheim, Chino, Culver City, Glendale
-
A Study to Evaluate the Safety, Tolerability, and PK of an Injectable Form of KarXT
NCT07061288 ·
Phase: Phase 1 ·
Ages: 18 Years to 55 Years ·
Sex: All (male and female)
· California: Los Alamitos
-
A Trial of the Efficacy and Safety of SEP-363856 in Acutely Psychotic Participants With Schizophrenia
NCT06894212 ·
Phase: Phase 3 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· California: Bellflower, Culver City, Garden Grove, Lemon Grove
-
An Adaptive Phase II/III, Two-Part, Double-Blind, Randomized, Placebo-controlled, Dose-Finding, Multi-center Study of the Safety and Efficacy of NaBen®, as an Add-on Therapy With Clozapine, for Residual Symptoms of Refractory Schizophrenia in Adults
NCT03094429 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years to 55 Years ·
Sex: All (male and female)
· California: Pasadena
-
Biomarkers to Enhance Early Schizophrenia Treatment
NCT06969755 ·
Phase: Phase 4 ·
Ages: 18 Years to 35 Years ·
Sex: All (male and female)
· California: La Jolla
-
Brain Stimulation to the Hippocampus in Schizophrenia
NCT07010614 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· California: Stanford
-
Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical Trial
NCT05208190 ·
Phase: Phase 4 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· California: Los Angeles
-
Context-Aware Mobile Intervention for Social Recovery in Serious Mental Illness (R33)
NCT06865937 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· California: San Diego
-
Determining Efficacy and Safety of BXCL501 in Agitation Associated With Pediatric Schizophrenia and Bipolar Disorder
NCT05025605 ·
Phase: Phase 1 ·
Ages: 10 Years to 17 Years ·
Sex: All (male and female)
· California: Anaheim
-
Determining the Role of Social Reward Learning in Social Anhedonia
NCT05617898 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 35 Years ·
Sex: All (male and female)
· California: Los Angeles
-
Effectiveness and Adverse-effect Switch Evaluation of Xanomeline and Trospium Chloride (KarXT)
NCT07379827 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· California: Anaheim, Chino, La Palma, Oceanside
-
Effects of Brain Stimulation on Cognition, Oscillations and GABA Levels in Schizophrenia
NCT04267003 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 47 Years ·
Sex: All (male and female)
· California: Sacramento
-
Effects of Cannabidiol (CBD) Versus Placebo as an Adjunct to Treatment in Early Psychosis
NCT04411225 ·
Phase: Phase 3 ·
Ages: 16 Years to 30 Years ·
Sex: All (male and female)
· California: La Jolla, San Diego
-
Efficacy and Safety of Cariprazine in the Treatment of Adolescent Participants (13 to 17 Years of Age) With Schizophrenia
NCT03817502 ·
Phase: Phase 3 ·
Ages: 13 Years to 17 Years ·
Sex: All (male and female)
· California: Culver City
-
Efficacy of NBI-1117568 in Preventing Relapse in Adults With Schizophrenia
NCT07227818 ·
Phase: Phase 3 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· California: Garden Grove, La Habra, Lemon Grove, Oceanside
-
Enhancing Rehabilitation for Veterans With Serious Mental Illness
NCT06586164 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 83 Years ·
Sex: All (male and female)
· California: San Diego
-
Enhancing Veteran-Clinical Collaboration in VA PRRCs
NCT06898879 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· California: San Diego, West Los Angeles
-
Evaluation of Treatment Satisfaction and KarXT Utilization Registry (RESKU)
NCT07101094 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· California: Costa Mesa, San Jose
-
Evenamide, a Glutamate Release Modulator, as Add-On to Standard of Care in Subjects With Documented Treatment-Resistant Schizophrenia
NCT07184619 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· California: Los Angeles
-
Imaging Synapses With [11C] UCB-J in the Human Brain
NCT04038840 ·
Phase: Phase 1 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· California: Palo Alto, Stanford
-
Improving Cognition Through Telehealth Aerobic Exercise and Cognitive Training After a First Schizophrenia Episode
NCT05890183 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 45 Years ·
Sex: All (male and female)
· California: Los Angeles
-
Inter-Brain Synchrony in Schizophrenia
NCT07177261 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· California: Los Angeles
-
Low-dose Buprenorphine as a Modulator of Social Motivation in Schizophrenia
NCT05778591 ·
Phase: Phase 2 ·
Ages: 18 Years to 60 Years ·
Sex: All (male and female)
· California: Los Angeles
-
MI-CBTech: A Mobile Intervention for Community Integration in Homeless-Experienced Veterans With SMI
NCT06138054 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· California: West Los Angeles
-
Medial-prefrontal Enhancement During Schizophrenia Systems Imaging
NCT04807530 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 64 Years ·
Sex: All (male and female)
· California: San Francisco
-
Multiomic Diagnostics in Youth With Psychosis
NCT05457140 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 7 Years to 17 Years ·
Sex: All (male and female)
· California: San Diego
-
NBI-1117568-SCZ3029: Evaluation of NBI-1117568 in Inpatient Adults With Schizophrenia
NCT06963034 ·
Phase: Phase 3 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· California: Anaheim, Pico Rivera, San Diego, Sherman Oaks
-
NBI-1117568-SCZ3030: Evaluation of NBI-1117568 in Inpatient Adults With Schizophrenia
NCT07105098 ·
Phase: Phase 3 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· California: Culver City, Garden Grove, Riverside
-
NBI-1117568-SCZ3032: Long-Term Evaluation of NBI-1117568 in Adults With Schizophrenia
NCT07114874 ·
Phase: Phase 3 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· California: Cerritos, Chino, Culver City, Garden Grove
-
Neural Basis of Social Cognition Deficits
NCT05185128 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 12 Years to 18 Years ·
Sex: All (male and female)
· California: Loma Linda
-
Neurophysiologic Biomarkers for Cognitive Rehabilitation
NCT05945602 ·
Phase: Not specified ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· California: San Diego
-
Randomized Clinical Trial of iTEST: A Blended Intervention Targeting Introspective Accuracy
NCT07098169 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· California: San Diego
-
Randomized Withdrawal Study in Patients With Schizophrenia
NCT06961968 ·
Phase: Phase 3 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· California: Costa Mesa, Lemon Grove, Oceanside, Pico Rivera
-
Relapse Prevention Trial Evaluating KarXT Treatment in Schizophrenia
NCT07686263 ·
Phase: Phase 3 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· California: Anaheim, Bellflower, Chino, Culver City
-
Sacramento Clinical High Risk for Psychosis Stepped-Care Program
NCT06640803 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 12 Years to 25 Years ·
Sex: All (male and female)
· California: Elk Grove, Sacramento
-
Safety and Efficacy of Brilaroxazine (RP5063) in Schizophrenia
NCT05184335 ·
Phase: Phase 3 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· California: Garden Grove, Lemon Grove, Riverside
-
Safety and Tolerability Trial of Lumateperone in Pediatric Patients With Schizophrenia, Bipolar Disorder or Autism Spectrum Disorder
NCT06229210 ·
Phase: Phase 3 ·
Ages: 5 Years to 17 Years ·
Sex: All (male and female)
· California: Anaheim, Garden Grove, Oceanside, Redlands
-
Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness
NCT06376734 ·
Phase: Phase 2 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· California: Sunnyvale
-
Single and Multiple Ascending Doses of NTX-253 in Healthy Participants and Participants With Stable Schizophrenia
NCT07344948 ·
Phase: Early Phase 1 ·
Ages: 18 Years to 55 Years ·
Sex: All (male and female)
· California: Los Alamitos
-
Study of ALTO-101 in Patients With Schizophrenia
NCT06502964 ·
Phase: Phase 2 ·
Ages: 21 Years to 55 Years ·
Sex: All (male and female)
· California: Garden Grove, Los Angeles, Orange, Walnut Creek
-
Study to Assess the Safety, Tolerability, and Treatment Response of GXV813 in Hospitalized Adults With Schizophrenia
NCT07467993 ·
Phase: Phase 2 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· California: Pico Rivera
-
Study to Evaluate Efficacy and Safety of Roluperidone in Adult Subjects With Negative Symptoms and Stable Positive Symptoms of Schizophrenia and to Evaluate the Relapse Rate of Roluperidone and Antipsychotic Medications
NCT07565428 ·
Phase: Phase 3 ·
Ages: 18 Years to 55 Years ·
Sex: All (male and female)
· California: Bellflower, Culver City, Garden Grove, Riverside
-
Study to Evaluate LB-102 for the Treatment of Adult Patients With Acute Schizophrenia
NCT07363577 ·
Phase: Phase 3 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· California: Culver City, Garden Grove, Lemon Grove, Riverside
-
Study to Evaluate Weight Gain as Assessed by Change in BMI Z-score in Pediatric Subjects With Schizophrenia or Bipolar I Disorder
NCT05303064 ·
Phase: Phase 3 ·
Ages: 10 Years to 17 Years ·
Sex: All (male and female)
· California: Encino, Stanford, Upland
-
Tolerability of MDMA in Schizophrenia
NCT05770375 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 60 Years ·
Sex: All (male and female)
· California: Los Angeles