Magnetic Resonance Spectroscopy Studies of Cardiac Muscle Metabolism
Recruiting · NCT00181259 · Observational (researchers observe without assigning treatment) · Lead sponsor: Johns Hopkins University
View the official record on ClinicalTrials.gov →What this trial is about
The metabolism of the heart provides the chemical energy needed to fuel ongoing normal heart contraction. Magnetic resonance spectroscopy is a technique used in a MRI scanner that can be used to measure and study heart metabolism directly but without blood sampling or obtaining tissue biopsies. One of the hypotheses this study aims to investigate is whether energy metabolism is reduced in heart failure and whether that contributes to the poor heart function.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- age \> 18 years
- Healthy subjects: no history of heart disease
- Dilated cardiomyopathy: history of heart failure, ejection fraction (EF) \<40%
- Left ventricular hypertrophy: wall thickness \>1.2cm
- Coronary artery disease: \>50% coronary lesion or positive stress test
Exclusion criteria
- contraindication to MRI
Where it is running
1 location listed across 1 US state.
- Johns Hopkins Medical Institutions - Baltimore, Maryland, United States