[18F]-Fluoro-2-Deoxy-D-Glucose and -[18F] Dihydro-Testosterone Pet Imaging in Patients With Progressive Prostate Cancer
Recruiting · NCT00588185 · Interventional (participants receive a specific treatment) · Lead sponsor: Memorial Sloan Kettering Cancer Center
View the official record on ClinicalTrials.gov →Interventions studied
[18F]-Fluoro-2-Deoxy-D-Glucose and -[18F] Dihydro-Testosterone
What this trial is about
This study will use PET scans, which is a type of x-ray test that uses a radiotracer, to see whether these scans may be better able to find places in the body where your prostate cancer may have spread.
Who can take part
Age range
No age limits stated
Sex
Male
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Patients with histologically confirmed prostate cancer.
- Progressive disease manifest by either:
- Imaging modalities:
- Bone Imaging: New osseous lesions on bone imaging (bone scintigraphy or NaF PET scan) and/or MRI or CT: An increase in measurable soft tissue disease, or the appearance of new sites of disease. Or
- Biochemical progression: A minimum of three rising PSA values from a baseline that are obtained 1 week or more apart, or 2 measurements 2 or more weeks apart.
- Visible lesions by either CT, bone imaging, or MRI consistent with disease.
- Informed consent.
Exclusion criteria
- Previous anaphylactic reaction to either FDHT or FDG
- Hepatic: Bilirubin \> 1.5 x upper limit of normal (ULN), AST/ALT \>2.5 x ULN, albumin \< 2 g/dl, and GGT \> 2.5 x ULN IF Alkaline phosphatase \> 2.5 x ULN
- Renal: Creatinine \>1.5 x ULN or creatinine clearance \< 60 mL/min
Where it is running
7 locations listed across 2 US states.
- Memorial Sloan Kettering Basking Ridge (Consent Only) - Basking Ridge, New Jersey, United States
- Memorial Sloan Kettering Monmouth (Consent only) - Middletown, New Jersey, United States
- Memorial Sloan Kettering Bergen (Consent Only) - Montvale, New Jersey, United States
- Memorial Sloan Kettering Commack (Consent only) - Commack, New York, United States
- Memorial Sloan Kettering Westchester (Consent only) - Harrison, New York, United States
- Memorial Sloan Kettering Cancer Center - New York, New York, United States
- Memorial Sloan Kettering Nassau (Consent Only) - Uniondale, New York, United States