COsegregation of VARiants in Panel of Genes
Recruiting · NCT01689584 · Interventional (participants receive a specific treatment) · Lead sponsor: Institut Curie
View the official record on ClinicalTrials.gov →Interventions studied
salivary kit
What this trial is about
The aim of the COVAR project is to achieve reliable classification of as many variants of interest as possible from the French OncoGenetics Database (FrOG, https://frog-db.fr/) in order to use them for the genetic counseling. The results obtained through this study will have a major impact on clinical management of the patients and their families conducting in some cases to propose a prophylactic surgery.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Index cases:
- A person carrying a variant of interest in a gene analyzed in a diagnostic setting by one of the laboratories within the Genetics and Cancer Group (GGC)-Unicancer network, classified as class 3, 4 or hypomorphic class 5, and selected by the national expert group for the gene concerned.
- Age ≥ 18 years.
- Signed written inform consent "index case"
- Related parties:
- Any relative of an index case with cancer
- Any relative without cancer related to an index case, selected by the investigators, according to family structure and degree of related compared to the index case
- For class 4 and hypomorphic class 5 variants; relatives currently undergoing analysis or having already obtained a test result for the variant of interest as part of clinical care.
- Age ≥ 18 years
- Information and signature of the informed consent "selected relatives"
Exclusion criteria
- Minors
- Persons deprived of liberty or under guardianship (including curators).
- Absence of signed written inform consent
Where it is running
60 locations listed.
- CHU Amiens - Hôpital Nord - Amiens, France
- ICO - Centre Paul Papin - Angers, France
- Centre Hospitalier d'Angoulème - Angoulême, France
- Institut Sainte-Catherine - Avignon, France
- CHU Besançon - Besançon, France
- Groupe Hospitalier Pellegrin - Bordeaux, France
- Institut Bergonié - Bordeaux, France
- Centre Hospitalier Jacques Coeur - Bourges, France
- CHU Morvan de Brest - Brest, France
- Centre François Baclesse - Caen, France
- Centre Hospitalier Hôtel Dieu - Chambéry, France
- Centre Jean Perrin - Clermont-Ferrand, France
- Hôpital Civil de Colmar - Colmar, France
- CHU de Dijon - Dijon, France
- CHU de Fort de France - Fort-de-France, Martinique
- CHU de Grenoble - Grenoble, France
- CHD Vendée - La Roche-sur-Yon, France
- Groupe Hospitalier La Rochelle-Ré-Aunis - La Rochelle, France
- Hôpital Flaubert - Le Havre, France
- Centre Oscar Lambret - Lille, France
- Chru Lille - Lille, France
- CHU Dupuytren - Limoges, France
- Hospices Civils de Lyon - Lyon, France
- Centre Léon Bérard - Lyon, France
- Institut Paoli Calmettes - Marseille, France
- CHU La Timone - Marseille, France
- CHU Arnaud de Villeneuve - Montpellier, France
- Centre Catherine de Sienne - Nantes, France
- Centre Antoine Lacassagne - Nice, France
- Centre Hospitalier Georges Renon - Niort, France
- Centre Hospitalier Territorial Gaston Bourret - Noumea, New Caledonia
- CHRU Caremeau - Nîmes, France
- Hôpital de la Source - Orléans, France
- Hôpital Saint-Antoine - Paris, France
- Groupe Hospitalier Pitié-Salpêtrière - Paris, France
- Hôpital Tenon - Paris, France
- Hôpital Saint-Louis - Paris, France
- HEGP - Paris, France
- CHU de Pointe à Pitre - Pointe-à-Pitre, Guadeloupe
- Centre Hospitalier Intercommunal Poissy -Saint Germain-en-Laye - Poissy, France
- CHU La Milétrie - Poitiers, France
- CHU de Reims - Reims, France
- ICC Courlancy - Reims, France
- Institut Jean Godinot - Reims, France
- Centre Eugène Marquis - Rennes, France
- CHU Rennes - Hôpital Sud - Rennes, France
- CHU de Rouen - Rouen, France
- CHU Saint Etienne - Saint-Etienne, France
- ICO - Centre René Gauducheau - Saint-Herblain, France
- CHU Sud Réunion Saint-Pierre - Saint-Pierre, Reunion
- CLCC Paul Strauss - Strasbourg, France
- Hopital de Hautepierre - Hôpital Universitaire - Strasbourg, France
- Institut Claudius Regaud - IUCT - Oncopole - Toulouse, France
- CHU Bretonneau - Tours, France
- CH Simone VEIL - Troyes, France
- Centre Hospitalier de Valence - Valence, France
- Centre Alexis Vautrin - Vandœuvre-lès-Nancy, France
- CHU Nancy - Hôpital Brabois - Vandœuvre-lès-Nancy, France
- Gustave Roussy - Villejuif, France
- Centre Hospitalier de Bastia - Bastia, Corsica, France
Showing 60 of 62 listed sites. See the official record for the complete list.
Read the full protocol, contacts and eligibility on ClinicalTrials.gov →