Safety and Durability of Sirolimus for Treatment of LAM
Recruiting · NCT02432560 · Observational (researchers observe without assigning treatment)
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
The MIDAS study aims to follow male and female LAM patients who are currently taking, have previously failed or been intolerant of, or may (at some time in the future) take mTOR inhibitors (sirolimus or everolimus) as part of their clinical care. Adult female TSC patients may also enroll, with or without lung cysts.
Who can take part
Age range
18 Years and older
Sex
Female
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Female or male, age 18 or over
- Diagnosis of LAM based on ATS/JRS criteria
- Signed and dated informed consent
- On chronic therapy, newly treated or may be considered for therapy with mTOR inhibitors or previously intolerant of or having failed mTOR inhibitor therapy
Exclusion criteria
- Inability to attend at least one RLD Clinic visit per year
- Inability to give informed consent
- Inability or unwillingness to perform pulmonary function testing
Where it is running
20 locations listed across 18 US states.
- Stanford University Medical Center - Stanford, California, United States
- National Jewish Health - Denver, Colorado, United States
- Mayo Clinic Jacksonville - Jacksonville, Florida, United States
- Emory University School of Medicine - Atlanta, Georgia, United States
- Loyola University Medical Center, Chicago - Maywood, Illinois, United States
- Brigham and Women's Hospital - Boston, Massachusetts, United States
- University of Michigan - Ann Arbor, Michigan, United States
- Mayo Clinic Rochester - Rochester, Minnesota, United States
- Washington University School of Medicine - St Louis, Missouri, United States
- University of Rochester Medical Center - Rochester, New York, United States
- University of Cincinnati - Cincinnati, Ohio, United States
- Cleveland Clinic - Cleveland, Ohio, United States
- Oregon Health and Science University - Portland, Oregon, United States
- University of Pennsylvania Medical Center - Philadelphia, Pennsylvania, United States
- Medical University of South Carolina - Charleston, South Carolina, United States
- Vanderbilt University Medical Center - Nashville, Tennessee, United States
- University of Texas Southwestern Medical Center - Dallas, Texas, United States
- University of Texas Health Center - Houston, Texas, United States
- University of Utah School of Medicine - Salt Lake City, Utah, United States
- Swedish Medical Center - Seattle, Washington, United States