Loop Diuretic Therapy in Acutely Decompensated Heart Failure
Recruiting · NCT02638142 · Observational (researchers observe without assigning treatment) · Lead sponsor: University of Siena
View the official record on ClinicalTrials.gov →Interventions studied
Continuous Furosemide InfusionIntermittent Furosemide Infusion
What this trial is about
DiurHF is a prospective, multicenter, observational, study that compares continuous with intermittent infusion of furosemide in patients admitted with a diagnosis of ADHF. Previous pilot study design was planned to anticipate a larger multicenter trial able to definitively evaluate the optimal loop diuretic use strategy in patients with ADHF.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Patients over 18 years;
- Patients with diagnosis of ADHF(dyspnea, orthopnea, peripheral edema or major fatigue and at least two clinical signs including rales, hepatomegaly, pulmonary congestion on chest radiography, jugular vein dilatation, or a third heart sound);
- Blood BNP \> 100 pg/mL;
- ADHF: Acute Decompensated Heart Failure; BNP: B-type Natriuretic Peptide; IV: IntraVenous; LVEF: Left Ventricular Ejection Fraction.
Exclusion criteria
- Patients who receive more than 40 mg of IV furosemide;
- End-Stage renal disease or renal replacement therapy;
- Recent myocardial infarction (within thirty days of screening);
- Systolic blood pressure \< 80 mmHg;
- Creatinine levels \> 4 mg/dL;
- Patients affected by sepsis, liver diseases, inflammatory diseases or neoplastic diseases.
Where it is running
4 locations listed.
- Azienda Ospedaliera di Padova - Padova, Italy
- University of Rome La Sapienza - Roma, Italy
- Department of Internal Medicine, Cardiovascular Diseases Unit - Siena, Italy
- Ospedale Madonna della Navicella - Chioggia, Venezia, Italy