Motor Slowing and Its Lesion-related Correlates in Alzheimer's Disease

Recruiting · NCT02811653 · Interventional (participants receive a specific treatment) · Lead sponsor: Centre Hospitalier Universitaire, Amiens

Interventions studied

BloodBrain MRIneuropsychological evaluation

In AD (Alzheimer disease), the anatomic correlates of attention disorders (as evaluated by motor slowing) have not been thoroughly characterized.

Age range

40 Years to 85 Years

Sex

All (male and female)

Healthy volunteers

Yes - healthy volunteers may be accepted

Phase

Not applicable (e.g. observational or device study)

Study type

Interventional (participants receive a specific treatment)

Patients
Age between 40 and 85
French mother tongue
Consulting at the Amiens Memory Resource and Research Centre (CMRR) for:
MCI, according to Albert et al.'s criteria (Albert et al., 2011)
Mild dementia (MMSE\>20) due to AD, according to McKhann's criteria (McKhann et al., 2011).
Mild dementia due to LBD, according to McKeith et al.'s criteria (McKeith et al., 2005).
Mild dementia due to FTLD, according to Rascovsky et al.'s criteria (Rascovsky et al., 2011).
Social security coverage
Healthy controls
Healthy age and gender matched volunteers will be recruited into the study from the general population.

Reading or writing difficulties related to a learning disorder or illiteracy.
A medical history with a potentially significant impact on cognition (non-corrected thyroid disorders or heart failure):
NYHA stage IV dyspnoea.
respiratory impairment requiring oxygen therapy.
liver impairment.
kidney failure, progressing neoplastic disease, or past or present alcohol abuse.
Past or present neurological disorders other than those having prompted consultation in the Memory Clinic:
stroke.
meningitis or encephalitis.
severe head injury.
sensorimotor impairments (sensory, proprioceptive, cerebellar and visual impairments).
epilepsy (requiring ongoing treatment),
psychiatric disorders (other than treated depression).
treatment with psychotropic medications (other than anxiolytics or antidepressant withdrawn or initiated in the previous month). Patients with parkinsonian syndrome were examined in the "on-drug" state.
Impossibility to perform a neuropsychological evaluation or brain MRI.
Withdrawal from the study at any time, if desired.
Pregnancy
Contra-indication to MRI:
nerve stimulators
cochlear implants
ferromagnetic foreign bodies close to nervous structures in the eye or brain
cerebral shunts
dental appliances
Legal guardianship or incarceration.

1 location listed.