Genetic Basis of Melanocytic Nevi
Recruiting · NCT03054584 · Observational (researchers observe without assigning treatment) · Lead sponsor: University of California, Davis
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
The objective of this protocol is to further elucidate the genetic mutations that drive melanocytic nevi (benign melanocytic neoplasms, moles). This will be performed by whole genome, whole exome, or targeted sequencing of de-identified specimens. Herein, the investigators plan to isolate DNA from de-identified skin biopsy specimens and blood samples: 1. From melanocytic nevi collected by skin biopsy (a shave or punch biopsy). A part of the tissue will be submitted for routine diagnostic dermatopathology and investigational histomorphologic and immunohistochemical analysis. 2. From corresponding normal tissue (blood). DNA isolated from blood will be used as a normal control when analyzing sequencing data to identify somatic mutations in lesional tissue.
Who can take part
Inclusion criteria
- Male or female subjects that are 18 years or older
- Subjects with melanocytic nevi\\
Exclusion criteria
- Patients less than 18 years of age
- Patients without melanocytic nevi
- Patients with a bleeding disorder or are taking anticoagulation medication
Where it is running
1 location listed across 1 US state.
- University of California-Davis, Department of Dermatology - Sacramento, California, United States