Retinal Imaging in Neurodegenerative Disease
Recruiting · NCT03233646 · Observational (researchers observe without assigning treatment) · Lead sponsor: Duke University
View the official record on ClinicalTrials.gov →Interventions studied
Retinal and Choroidal Imaging
What this trial is about
This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the retinal and choroidal microvasculature and structure in persons with mild cognitive impairment (MCI) and Alzheimer's Disease (AD), Parkinson's Disease (PD), or other neurodegenerative disease, diseases as outlined.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Adults with neurodegenerative disease ((MCI, PD, AD, FTD, DLB, ALS, MS, HD, TBI, concussion, PTSD and other neurodegenerations as well as Down Syndrome)
- Adults without neurodegenerative disease
Exclusion criteria
- Inability to cooperate with or complete testing or other neurologic or age- related ocular conditions that would impact image acquisition.
- Eyes that have had intraocular surgery, other than cataract surgery.
- If two eyes satisfy the inclusion criteria, both eyes will be included in the study. If one eye satisfies the inclusion criteria, the eye that qualifies will be included in the study.
Where it is running
3 locations listed across 1 US state.
- Duke University Medical Center - Durham, North Carolina, United States
- Duke University Medical Center - Durham, North Carolina, United States
- Duke University Medical Center - Durham, North Carolina, United States