Heart Failure and Aortic Stenosis Transcriptome
Recruiting · NCT03268135 · Observational (researchers observe without assigning treatment) · Lead sponsor: IRCCS Policlinico S. Donato
View the official record on ClinicalTrials.gov →Interventions studied
measurement of RNAs
What this trial is about
This study is aimed to investigate the global transcriptome in order to determine the expression profile of messenger RNAs (mRNAs), as well as long noncoding- (lncRNAs) and micro noncoding-RNAs (miRNAs) in heart failure (HF) and in aortic stenosis (AS). The aim is to clarify their role in cardiac disease pathogenesis, as well as their potential as biomarkers. To this purpose, both tissue and blood specimens will be collected and patients will be compared to individuals not affected by cardiovascular diseases.
Who can take part
Age range
40 Years to 75 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Non end-stage heart failure
- left ventricle restoration surgery (SVR)
- End Systolic Volume Index (ESVI) \>35 ml/m2
- Ejection Fraction (EF)\<40%
- previous transmural anterior myocardial infarction (MI)
- age: 40-75
- End-stage heart failure
- left ventricle assisted device (LVAD) surgery
- age: 40-75
- Ejection Fraction (EF) \<25%
- End Systolic Volume Index (ESVI)≥60 ml/m2
- Aortic Stenosis
- aortic valve replacement
- intracardial pressure difference \>40 mmHg
- septal diameter ≥1.3 cm
Exclusion criteria
- Non end-stage heart failure
- End Systolic Volume Index (ESVI)\<35 ml/m2
- Ejection Fraction (EF)\>40%
- Time from MI unknown
- Pregnancy
- Other genetic diseases
- Neoplasms
- Collagenopathies
- Chemo/radiotherapy
- Prolonged use of corticosteroids
- Infections
- Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV) (not vaccination) and Hepatitis C Virus (HCV) positive
- End-stage heart failure
- EF\>25%
- Time from MI unknown
- Pregnancy
- Other genetic diseases
- Neoplasms
- Collagenopathies
- Chemo/radiotherapy
- Prolonged use of corticosteroids
- Infections
- Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV) (not vaccination) and Hepatitis C Virus (HCV) positive
- Aortic Stenosis
- coronaropathies
- Pregnancy
- Other genetic diseases
- Neoplasms
- Collagenopathies
- Chemo/radiotherapy
- Prolonged use of corticosteroids
- Infections
- Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV) (not vaccination) and Hepatitis C Virus (HCV) positive
Where it is running
2 locations listed.
- Ospedale San Raffaele - Milan, Italy
- Irccs Policlinico San Donato - San Donato Milanese, Milan, Italy