A Study of Blood Based Biomarkers for Pancreas Adenocarcinoma

Inclusion criteria

• Cohort 1: Advanced Pancreatic Cancer Cohort Inclusion Criteria
• Radiological, histological or cytological confirmed diagnosis of locally advanced or metastatic pancreatic adenocarcinoma by the enrolling institution
• Patient planning to receive systemic treatment
• Hemoglobin \> 8
• ECOG performance status 0-2
• A minimum age of 18 years old
• Willing to provide permission to obtain banked tumor tissue for analysis (previous biopsies or surgical material).
• Cohort 2: Operable Pancreatic Cancer Cohort Inclusion Criteria
• Radiological, histological or cytological confirmed diagnosis of pancreatic adenocarcinoma by the enrolling institution
• Patient planned to undergo upfront resection
• No pre-operative systemic therapy nor chemoradiation therapy planned
• Hemoglobin \> 8
• ECOG performance status 0-2
• A minimum age of 18 years old
• Willing to provide permission to obtain banked tumor tissue for analysis (previous biopsies or surgical material).
• Cohort 3: Acute Benign Pancreatic Pathology Control Inclusion Criteria
• Confirmed diagnosis of acute pancreatitis or other acute pancreatic pathology by the enrolling institution
• Hemoglobin \> 8
• ECOG performance status 0-2
• A minimum age of 18 years old
• Cohort 4: Chronic Benign Pancreatic Pathology Control Inclusion Criteria
• Confirmed diagnosis of chronic pancreatitis or other non-cystic chronic pancreatic pathology by the enrolling institution
• Hemoglobin \> 8
• ECOG performance status 0-2
• A minimum age of 18 years old
• Cohort 5: IPMN Control Inclusion Criteria
• Confirmed diagnosis of IPMN without high risk features by the enrolling institution
• A minimum age of 18 years old
• Cohort 6: Pancreatic Cyst Control Inclusion Criteria
• Confirmed diagnosis of benign pancreatic cyst by the enrolling institution
• A minimum age of 18 years old
• Cohort 7: Healthy Control Inclusion Criteria
• A minimum age of 18 years old

Exclusion criteria

• Cohort 1: Advanced Pancreatic Cancer Cohort Exclusion Criteria
• Prior chemotherapy or radiation therapy for pancreatic cancer within the last 3 months in the localized setting
• Active second malignancy, unless low grade malignancy
• Any medical or psychiatric condition that may interfere with ability to comply with protocol procedures
• Cohort 2: Operable Pancreatic Cancer Cohort Exclusion Criteria
• Neoadjuvant chemotherapy or radiation therapy is planned
• Active second malignancy, unless low grade malignancy
• Any medical or psychiatric condition that may interfere with ability to comply with protocol procedures
• Cohort 3: Acute Benign Pancreatic Pathology Control Exclusion Criteria
• Active or prior malignancy, except prior non-melanoma skin cancer
• Proven to be a carrier of a cancer susceptibility gene or family history concerning for genetic predisposition to cancer
• Any medical or psychiatric condition that may interfere with ability to comply with protocol procedures
• Cohort 4: Chronic Benign Pancreatic Pathology Control Exclusion Criteria
• Active or prior malignancy, except prior non-melanoma skin cancer
• Proven to be a carrier of a cancer susceptibility gene or family history concerning for genetic predisposition to cancer
• Any medical or psychiatric condition that may interfere with ability to comply with protocol procedures
• Cohort 5: IPMN Control Exclusion Criteria
• IPMN with high risk features or planned resection
• Active or prior malignancy, except prior non-melanoma skin cancer
• Proven to be a carrier of a cancer susceptibility gene or family history concerning for genetic predisposition to cancer
• Any medical or psychiatric condition that may interfere with ability to comply with protocol procedures
• Cohort 6: Pancreatic Cyst Control Exclusion Criteria
• Active or prior malignancy, except prior non-melanoma skin cancer
• Proven to be a carrier of a cancer susceptibility gene or family history concerning for genetic predisposition to cancer
• Any medical or psychiatric condition that may interfere with ability to comply with protocol procedures
• Cohort 7: Healthy Control Exclusion Criteria
• Active or prior malignancy, except prior non-melanoma skin cancer
• Proven to be a carrier of a cancer susceptibility gene or family history concerning for genetic predisposition to cancer
• Any medical or psychiatric condition that may interfere with ability to comply with protocol procedures