Comprehensive Assessment of Neurodegeneration and Dementia
Recruiting · NCT03402919 · Observational (researchers observe without assigning treatment) · Lead sponsor: McGill University
View the official record on ClinicalTrials.gov →What this trial is about
This is a longitudinal observational study recruiting individuals between the ages of 50 and 90 with different types of dementia as well as a comparison group without cognitive deficits. Participants are/will be recruited at sites across Canada and will undergo assessments, neuroimaging, and biological sample collection.
Who can take part
Age range
50 Years to 90 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Has subjective or objective cognitive impairment
- Written informed consent must be obtained and documented (from the patient or, where jurisdictions allow it, from a caregiver/family member)
- Sufficient proficiency in English or French to undertake self report and neuropsychological testing
- Geographic accessibility to the study site
- Must have a study partner who can participate as required in the protocol (provide corroborative information)
- Up to 12 years of education
- Fits into one of the following groups: Cognitively Unimpaired, Subjective Cognitive Impairment, Mild Cognitive Impairment, Vascular Mild Cognitive Impairment, Parkinson's Disease, Parkinson's Disease with Mild Cognitive Impairment
Exclusion criteria
- The presence of other significant known chronic brain disease such as: moderate to severe chronic static leukoencephalopathy (including previous traumatic injury), multiple sclerosis, a serious developmental handicap, malignant tumors, Parkinson's disease (other than for the Parkinson's cohort), and other rarer brain illnesses
- Ongoing alcohol or drug abuse which in the opinion of the investigator may interfere with the subject's ability to comply with the study procedures
- Symptomatic stroke within the previous year
- Unable to undergo MRI scan due to medical contraindications or inability to tolerate the procedure
Where it is running
19 locations listed.
- University of Calgary - Calgary, Alberta, Canada
- University of Alberta Hospital - Edmonton, Alberta, Canada
- Djavad Mowafaghian Centre for Brain Health - Vancouver, British Columbia, Canada
- Island Health - Victoria, British Columbia, Canada
- Veteran's Memorial Building - Halifax, Nova Scotia, Canada
- Hamilton General Hospital - Hamilton, Ontario, Canada
- St. Joseph's Health Care London - London, Ontario, Canada
- Gait and Brain Lab - London, Ontario, Canada
- Bruyère Research Institute - Ottawa, Ontario, Canada
- Kawartha Centre - Peterborough, Ontario, Canada
- Sunnybrook Health Sciences Centre - Toronto, Ontario, Canada
- University Health Network Memory Clinic - Toronto, Ontario, Canada
- Baycrest Clinical Unit - Toronto, Ontario, Canada
- University of Waterloo - Waterloo, Ontario, Canada
- Research Institute of the McGill University Health Centre - Montreal, Quebec, Canada
- Jewish General Hospital/McGill Memory Clinic - Montreal, Quebec, Canada
- Clinique de cognition Institut universitaire de gériatrie de Montréal - Montreal, Quebec, Canada
- Hôpital Enfant-Jésus - Québec, Quebec, Canada
- Centre de recherche sur le vieillissement CIUSSS de l'Estrie-CHUS - Sherbrooke, Quebec, Canada