SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

Recruiting · NCT03452774 · Observational (researchers observe without assigning treatment) · Lead sponsor: Massive Bio, Inc.

View the official record on ClinicalTrials.gov →

Colorectal cancer Pancreatic cancer Prostate cancer Lung cancer Melanoma Breast Cancer

Interventions studied

Clinical Trial Matching

What this trial is about

International registry for cancer patients evaluating the feasibility and clinical utility of an Artificial Intelligence-based precision oncology clinical trial matching tool, powered by a virtual tumor boards (VTB) program, and its clinical impact on pts with advanced cancer to facilitate clinical trial enrollment (CTE), as well as the financial impact, and potential outcomes of the intervention.

Who can take part

Age range

No age limits stated

Sex

All (male and female)

Healthy volunteers

No - a diagnosis or condition is required

Phase

Not specified

Study type

Observational (researchers observe without assigning treatment)

Inclusion criteria

Pts with solid and hematological malignancies;
Pts cancer-related biomarkers, gene variants, fusion and rearrangements (by immunohistochemistry, PCR, FISH or NGS): PD-L1, MSI (MMR), Claudin18.2, HER2/Neu, Tumor mutational burden/load (TMB), ABL1, ACVR1B, AKT1, AKT2, AKT3, ALK, APC, AR, ATM, ATRX, AURKA, AURKB, BAP1, BCL2, BCL6, BRAF, BRCA1, BRCA2, BTK, CCND1, CCND2, CCND3, CDK4, CDK6, CDKN1A/B, CEBPA, CHEK1, CHEK2, CSF1R, CTNNB1, DAXX, DDR1/2, DNMT3A, EGFR, ERBB2, ERBB3, ERBB4, ERCC4, ER, ESR1, FANCA, FAS, FBXW7, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, GATA3, GATA6, GNAS, HDAC1, HGF, HRAS, IDH1, IDH2, IGF1R, JAK1, JAK2, JAK3, KDR (VEGFR2), KIT, KRAS, MAP2K2 (MEK2), MAP3K1, MCL1, MDM2, MDM4, MEN1, MET, MSH2, MSH3, MSH6, MTOR, MUTYH, MYC, MYCL (MYCL1), NF1, NF2, NOTCH1, NPM1, NRAS, NTRK1, NTRK2, NTRK3, PALB2, PARP1, PARP2, PARP3, PBRM1, PDCD1 (PD1), PDCD1LG2 (PD-L2), PDGFRA, PDGFRB, PIK3C, PMS2, POLD1, POLE, PRDM1, PTCH1, PTEN, RAF1, RB1, RET, RICTOR, ROS1, RPTOR, SDHA/B/C, SMAD, SMARC, SMO, STK11, TGFBR2, TP53, TSC1, TSC2, VEGFA, VHL, WT1, ZNF217, ZNF703, CEACAM, NRG1, among others.
These biomarkers should be determined by local laboratory, external vendor, or next generation sequencing platform
Decision to consider clinical trial pre-screening enrollment (CTE) by primary provider and/or patient

Exclusion criteria

ECOG PS \> 2;
Abnormal organ function;
Hospice enrollment

Where it is running

60 locations listed across 40 US states.

Massive Bio SYNERGY-AI site - Birmingham, Alabama, United States
Massive Bio SYNERGY-AI site - Birmingham, Alabama, United States
Massive Bio SYNERGY-AI site - Birmingham, Alabama, United States
Massive Bio SYNERGY-AI site - Mobile, Alabama, United States
Massive Bio SYNERGY-AI site - Mobile, Alabama, United States
Massive Bio SYNERGY-AI site - Mobile, Alabama, United States
Massive Bio SYNERGY-AI site - Scottsdale, Arizona, United States
Massive Bio SYNERGY-AI site - Scottsdale, Arizona, United States
Massive Bio SYNERGY-AI site - Scottsdale, Arizona, United States
Massive Bio SYNERGY-AI site - Little Rock, Arkansas, United States
Massive Bio SYNERGY-AI site - Little Rock, Arkansas, United States
Massive Bio SYNERGY-AI site - Little Rock, Arkansas, United States
Massive Bio SYNERGY-AI site - Duarte, California, United States
Massive Bio SYNERGY-AI site - Duarte, California, United States
Massive Bio SYNERGY-AI site - Duarte, California, United States
Massive Bio SYNERGY-AI site - Irvine, California, United States
Massive Bio SYNERGY-AI site - Irvine, California, United States
Massive Bio SYNERGY-AI site - Irvine, California, United States
Massive Bio SYNERGY-AI site - La Jolla, California, United States
Massive Bio SYNERGY-AI site - La Jolla, California, United States
Massive Bio SYNERGY-AI site - La Jolla, California, United States
Massive Bio SYNERGY-AI site - Orange, California, United States
Massive Bio SYNERGY-AI site - Orange, California, United States
Massive Bio SYNERGY-AI site - Orange, California, United States
Massive Bio SYNERGY-AI site - San Francisco, California, United States
Massive Bio SYNERGY-AI site - San Francisco, California, United States
Massive Bio SYNERGY-AI site - San Francisco, California, United States
Massive Bio SYNERGY-AI site - Stanford, California, United States
Massive Bio SYNERGY-AI site - Stanford, California, United States
Massive Bio SYNERGY-AI site - Stanford, California, United States
Massive Bio SYNERGY-AI site - Aurora, Colorado, United States
Massive Bio SYNERGY-AI site - Aurora, Colorado, United States
Massive Bio SYNERGY-AI site - Aurora, Colorado, United States
Massive Bio SYNERGY-AI site - Denver, Colorado, United States
Massive Bio SYNERGY-AI site - Denver, Colorado, United States
Massive Bio SYNERGY-AI site - Denver, Colorado, United States
Massive Bio SYNERGY-AI site - Littleton, Colorado, United States
Massive Bio SYNERGY-AI site - Littleton, Colorado, United States
Massive Bio SYNERGY-AI site - Littleton, Colorado, United States
Massive Bio SYNERGY-AI site - Hartford, Connecticut, United States
Massive Bio SYNERGY-AI site - Hartford, Connecticut, United States
Massive Bio SYNERGY-AI site - Hartford, Connecticut, United States
Massive Bio SYNERGY-AI site - Norwalk, Connecticut, United States
Massive Bio SYNERGY-AI site - Norwalk, Connecticut, United States
Massive Bio SYNERGY-AI site - Norwalk, Connecticut, United States
Massive Bio SYNERGY-AI site - Newark, Delaware, United States
Massive Bio SYNERGY-AI site - Newark, Delaware, United States
Massive Bio SYNERGY-AI site - Newark, Delaware, United States
Massive Bio SYNERGY-AI site - Jacksonville, Florida, United States
Massive Bio SYNERGY-AI site - Jacksonville, Florida, United States
Massive Bio SYNERGY-AI site - Jacksonville, Florida, United States
Massive Bio SYNERGY-AI site - Miami, Florida, United States
Massive Bio SYNERGY-AI site - Miami, Florida, United States
Massive Bio SYNERGY-AI site - Miami, Florida, United States
Massive Bio SYNERGY-AI site - Tampa, Florida, United States
Massive Bio SYNERGY-AI site - Tampa, Florida, United States
Massive Bio SYNERGY-AI site - Tampa, Florida, United States
Massive Bio SYNERGY-AI site - Atlanta, Georgia, United States
Massive Bio SYNERGY-AI site - Atlanta, Georgia, United States
Massive Bio SYNERGY-AI site - Atlanta, Georgia, United States

Showing 60 of 204 listed sites. See the official record for the complete list.

Read the full protocol, contacts and eligibility on ClinicalTrials.gov →