The Venous Distension Reflex and Orthostatic Hypertension
Recruiting · NCT03496792 · Interventional (participants receive a specific treatment) · Lead sponsor: Milton S. Hershey Medical Center
View the official record on ClinicalTrials.gov →Interventions studied
Limb occlusion + negative pressureLimb occlusion + no negative pressureTilt + external pressureTilt + no external pressure.
What this trial is about
This research is being done to find out whether distension of veins in legs will cause a rise in blood pressure (orthostatic hypertension).
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Are capable of giving informed consent
- Are of any race or ethnicity
- Are fluent in written and spoken English
- Whose history and physical exam did not uncover any
Exclusion criteria
- Are 18 years of age
- For subjects with elevated standing BP
- Systolic BP (SBP) during standing is at least 10 mmHg \> the supine SBP
- Patients with a diagnosis of stage I hypertension without other chronic diseases may be INCLUDED
- For normal subjects without elevated standing BP
- The change in SBP by standing is within ± 5 mmHg from the supine SBP
- Matched gender, similar age and BMI (within 10%) to participants with elevated standing BP
- Free of acute or chronic medical conditions
- Exclusion Criteria:
- Age \< 18 years of age
- Are a pregnant or nursing woman
- Are a prisoner or institutionalized individual or unable to consent
- Have chronic diseases (e.g. heart, lung, neuromuscular disease, or cancer) other than stage I hypertension
- Have orthostatic hypotension or a history of syncope
- Current smoker
- History of blood clots
Where it is running
1 location listed across 1 US state.
- Penn State Milton S. Hershey Medical Center - Hershey, Pennsylvania, United States