Validating Novel, Non-contrast Cardiac MRI Imaging in Haemodialysis Patients
Recruiting · NCT03586518 · Observational (researchers observe without assigning treatment) · Lead sponsor: University of Leicester
View the official record on ClinicalTrials.gov →Interventions studied
48-Hour continuous cardiac monitoringBlood samplesCardiac MRI scanCardiac explantationEchocardiogram
What this trial is about
There are currently no good ways of measuring levels of scarring in the hearts of patients with advanced kidney disease and patients on dialysis, although recent research has shown a new cardiac MRI technique, called native T1 mapping, may provide a solution to this. To assess the accuracy of this novel technique in dialysis patients, it is essential to undertake a study which compares native T1 mapping to actual levels of scarring in the hearts of patients on dialysis.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Prevalent haemodialysis patient (more than 3 months)
- Active on the supportive care register with anticipated death in the subsequent 12 months
- Able to give informed consent
- Consent to donation of heart for research following death
- Able to understand written and verbal explanations in English
Exclusion criteria
- Contraindication to MRI scan (e.g. pacemaker, incompatible metallic implants, claustrophobia)
- Patients with expected or potential infiltrative cardiomyopathy (e.g. amyloidosis)
- Unable to give informed consent
- Unable to understand written and verbal explanations in English
Where it is running
1 location listed.
- University Hospitals of Leicester NHS Trust - Leicester, Leicestershire, United Kingdom