Biological Bank for Atrial Fibrillation and Stroke
Recruiting · NCT03611816 · Observational (researchers observe without assigning treatment) · Lead sponsor: Hospices Civils de Lyon
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
Atrial fibrillation (AF) is the most common cardiac arrhythmia encountered in clinical practice. This arrhythmia is responsible for 15% of strokes and more than 30% of strokes on people over 65 years. According to studies, 30 to 40% of isolated atrial fibrillations could be familial. Atrial fibrillation has significant genetic heterogeneity. About 40 genes have been identified as potentially involved. Studies have identified genes common to the risk of atrial fibrillation and stroke. Despite the pathophysiology of atrial fibrillation has been intensively and extensively studied for almost a century, there are still many questions. The pathophysiology is not sufficiently understood to allow finding more effective therapies. It is necessary to identify genetic determinants and thus potentially new pharmacological targets more adapted. The establishment of a biological database will test hypotheses concerning the genetic origin and thromboembolic process of atrial fibrillation and associated stroke.
Who can take part
Inclusion criteria
- \- AF history
Exclusion criteria
- No AF history
- patient who didn't signed consent
- Group 1b
- Inclusion Criteria :
- AF history
- Scheduled electrophysiological exploration or AF ablation
- Exclusion Criteria :
- No AF history
- pregnant women
- patient who didn't signed consent
- Group 1c
- Inclusion Criteria :
- AF/AT history
- Stroke history
- Exclusion Criteria :
- No Stroke history
- patient who didn't signed consent
- Group 2
- Inclusion Criteria :
- patient over 80
- ECG: sinusal rhythm
- TTE : no left atrial dilatation
- Exclusion Criteria :
- atrial fibrillation history
- TTE : Left atria \>25cm², \> 34m/m2), FEVG \< 50%
- ECG : QRS \> 90 ms
- cardiac pathologies (excepted hypertension and valvulopathies)
- History of stroke and transient ischemic attack
- patient who didn't signed consent
- Group 3
- Inclusion Criteria :
- cryptogenic stroke or transient ischemic attack history before 50 yo
- No AF history
- Exclusion Criteria :
- AF history
- stroke or transient ischemic attack over 50 yo
- patient who didn't signed consent
Where it is running
5 locations listed.
- Service neurologie Centre hospitalier Fleyriat - Bourg-en-Bresse, France
- Service d'urgences Neurovasculaires - service de neurologie vasculaire , Hôpital Pierre Wertheimer - Bron, France
- Service de rythmologie, hôpital cardiologique Louis Pradel - Bron, France
- Service de médecine gériatrique Centre hospitalier Lyon Sud, Groupement hospitalier Sud - Pierre-Bénite, France
- Hôpital des charpennes - Villeurbanne, France