Cardiovascular Prevention Strategies in Elderly Patients With Cancer (CARTIER Clinical Trial)
Recruiting · NCT03711110 · Interventional (participants receive a specific treatment) · Lead sponsor: Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
The CARTIER study is a randomized, multicenter, open-label clinical trial comparing, in elderly patients with cancer under anti-tumoral treatment, two different cardiotoxicity prevention strategies: primary (intensive cardiovascular monitoring focused on prevention and early diagnosis and treatment of cardiotoxicity based in cardio-onco-hematology teams involved in cancer patient care) vs. secondary (current clinical practice where intensive cardiovascular monitoring is not routinely performed and cardiotoxicity patient care is based on the onco-hematologist criteria). The primary endpoint is to determine whether this primary prevention englobing cardiovascular monitoring plus intensive multidisciplinary management is superior to the current clinical practice in reducing all cause mortality. Other secondary objectives of the study are to analyze the impact of this intensive cardiovascular monitoring strategy on the incidence of cardiovascular mortality, oncological mortality, hospitalization and/or urgent care due to cardiovascular complications, hospitalization and/or urgent oncological care due to cancer complications, tumor progression and cost-effectiveness analysis. A total of 514 patients ≥ 65 years old diagnosed with any of the following onco-hematological cancers, colon, breast, lymphoma, chronic lymphoma leukemia, chronic myeloid leukemia or myeloma, undergoing standardized anti-tumoral treatment, will be recruited. The incidence of primary and secondary outcomes will be measured at 2 and 5 years
Who can take part
Inclusion criteria
- \> 65 years old
- Expected survival \>1 year
- Colon cancer, breast cancer, lymphoma, chronic lymphoma leukemia, chronic myeloid leukemia, myeloma
- Signature on the informed consent
Exclusion criteria
- Patients included in clinical trials will be excluded if they interfere with the CARTIER follow-up protocol. If they do not interfere they can be included
- Patients who had received previous potentially cardiotoxic anticancer treatment
Where it is running
14 locations listed.
- Hospital Universitario Vall d´Hebron - Barcelona, Spain
- Hospital Universitario Reina Sofía - Córdoba, Spain
- Hospital Universitario de La Princesa - Madrid, Spain
- Hospital G. Universitario Gregorio Marañón - Madrid, Spain
- Hospital Universitario Ramón y Cajal - Madrid, Spain
- Hospital Universitario Fundación Jiménez Díaz - Madrid, Spain
- Hospital Universitario 12 de Octubre - Madrid, Spain
- Hospital Universitario Puerta de Hierro - Madrid, Spain
- Hospital Universitario Virgen de la Victoria - Málaga, Spain
- Complejo Asistencial Universitario de Salamanca - Salamanca, Spain
- Hospital Universitario Virgen del Rocío - Seville, Spain
- Hospital Universitario Río Hortega - Valladolid, Spain
- Hospital Clínico Universitario de Santiago de Compostela - Santiago de Compostela, A Coruña, Spain
- Hospital de Galdakao-Usansolo - Galdakao, Vizcaya, Spain