Diagnosis of Renal Osteodystrophy in Patients With Reduced Renal Function
Recruiting · NCT03716128 · Observational (researchers observe without assigning treatment) · Lead sponsor: Ditte Hansen
View the official record on ClinicalTrials.gov →Interventions studied
18F-PET
What this trial is about
The aim of the study is to 1. To describe the bone morphology in patients with reduced renal function and high or low parathyroid hormone (PTH) respectively. 2. To investigate if the non-invasive method 18-Fluoride Positron Emission Tomography (18F-PET) can describe the bone turnover and reflect the bone histomorphologic changes 3. To investigate if non-oxidized PTH reflects bone turnover
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- ≥ 18 years
- estimated Glomerular Filtration Rate (eGFR) ≤ 20 ml/min/1,73m2
- PTH \< 150 pg/ml or PTH \> 300 pg/ml
Exclusion criteria
- ongoing malignancy
- Allergy towards tetracyclin
- Pregnancy
- Control Group:
- Inclusion Criteria:
- ≥ 18 years
- eGFR \>= 60 ml/min
- under examination for c prostata
- Prostatic Specific Antigen (PSA) total \<40 µg/l
- Exclusion:
- Former kidney disease
- ionized calcium or PTH outside normal range
- Known metabolic bone disease
- treatment with anticoagulants
- Disturbed thrombosis and hemostasis
Where it is running
1 location listed.
- Herlev Hospital - Herlev, Denmark