Mechanisms of Pregnancy Vascular Adaptations
Recruiting · NCT03806283 · Observational (researchers observe without assigning treatment)
View the official record on ClinicalTrials.gov →Interventions studied
Omental Biopsy
What this trial is about
The investigators will collect omental tissue (research surgical excision) and placental tissue (standard of care clinical delivery) from both preeclamptic and non-preeclamptic women during their c-section and use these samples to study the blood vessels, specifically the expression/activation of the AT2R.
Who can take part
Age range
18 Years to 40 Years
Sex
Female
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Female
- Ages 18 to 40 years old
- Singleton gestation between 28 weeks, 0 days and 41 weeks, 0 days gestational age at the time of consent
- Undergoing caesarean section, either planned or otherwise with or without trial of labor
Exclusion criteria
- Treatment of severe hypertension by antihypertensive or use of magnesium sulfate after the patient is hospitalized for the diagnosis of preeclampsia.
- Any major fetal structural anomalies or aneuploidies
- Undergoing cesarean section for placental abruption or bleeding complications.
- Singleton gestation not within 36 weeks, 0 days and 41 weeks, 0 days gestational age at the time of enrollment (delivery)
Where it is running
1 location listed across 1 US state.
- UnityPoint Health-Meriter Hospital - Madison, Wisconsin, United States