Noninvasive Elastography Evaluation of Myocardial Stiffness in Elderly Patients With Isolated Diastolic Heart Failure: New Diagnostic Tool?
Recruiting · NCT03895541 · Interventional (participants receive a specific treatment) · Lead sponsor: French Cardiology Society
View the official record on ClinicalTrials.gov →Interventions studied
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What this trial is about
The new approach propose in this protocol is based on ultrafast ultrasound and remote palpation of tissue by ultrasonic radiation pressure. Ultrafast ultrasound of biological tissues is based on an innovative ultrasound imaging approach that can image very fast soft tissue events at a rate of several thousands of frames per second and provide quantitative mapping of the elasticity of the tissues. This current project aims is to focus on myocardial rigidity in diastole to better assess the function of the heart failure.
Who can take part
Age range
60 Years to 80 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Hospitalization in cardiology services for acute pulmonary edema during heart failure
- Natriuretic peptide type B ≥35 pg/ml
- Echocardiographic structural alteration
- Specific Inclusion criteria
- Group "preserved LVEF": Left ventricular Ejection Fraction ≥50%
- Group "moderate alteration of LVEF": Left ventricular Ejection Fraction between 40% and 49%
- Group "Systolic heart failure": Left ventricular Ejection Fraction\< 40%
- Global
Exclusion criteria
- Other associated lung pathology
- Other heart disease
- Contraindication to MRI or echocardiography gel
- Pregnancy
- Poor echogenicity,
Where it is running
1 location listed.
- Emmanuel MESSAS - Paris, France