DBS and Respiration
Recruiting · NCT04058457 · Observational (researchers observe without assigning treatment) · Lead sponsor: University of Oxford
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
Patients referred to neurosurgery routinely and safely undergo deep brain stimulation (DBS) for treatment of neurological conditions, most commonly Parkinson's disease. The investigators have observed that respiratory problems (breathlessness) sometimes occur subsequent to DBS of the subthalamic nucleus (STN). This study aims to determine whether this is indeed a consequence of STN stimulation. Secondary objectives include identification of the respiratory physiological mediators of any interoceptive neuromodulation observed, changes in daily physical activity and MRI structural connectivity analysis.
Who can take part
Inclusion criteria
- Participant is willing and able to give informed consent for participation in the study.
- Male or female, aged 18 years or above.
- Planned for required DBS surgery
- Fluent in the English language
- For experimental group: diagnosed with Parkinson's disease
Exclusion criteria
- Female who is pregnant
- Subject is currently participating in a clinical investigation that includes an active treatment arm which may affect the respiratory system.
- Acute respiratory problem at time of experimental session: e.g. rhinosinusitis, pharyngitis, asthma exacerbation
Where it is running
1 location listed.
- John Radcliffe Hospital - Oxford, Oxfordshire, United Kingdom