Pre-therapeutic MRI Assessment of Early-Stage Rectal Cancer and Significant Rectal Polyps to Avoid Major Resectional Surgery
Recruiting · NCT04103372 · Interventional (participants receive a specific treatment) · Lead sponsor: Imperial College London
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
When a patient is diagnosed with a rectal (bowel) polyp or cancer, radiology doctors read MRI scans to describe how deeply the cancer invades into the bowel wall (this is the 'stage' of the cancer). In this project, we will teach radiologists to find more early-stage rectal cancers. These are cancers that have only grown partially into the bowel wall. If we succeed, more patients could have these lesions removed by a local procedure that preserves the bowel and avoids the risks and complications of major surgery. We have developed a new method for radiology doctors to read MRI scans, which is more accurate than current practice. Currently only 3/10 of early rectal cancers are found by radiologists but by using our MRI reading system, 9/10 patients can be accurately identified as having early rectal cancer. We have proven that we can teach this method to other radiology doctors whose reports help to accurately inform patients of all possible treatment options, so they can be offered the option of a local procedure. In this initial work we will train radiology doctors in our MRI reading method in 20 hospitals. We will compare MRI reports before and after training to see if an accurate reading method improves treatments choices for patients. We will also determine whether more patients have local procedures after our training. The results of this initial work will help us to apply for national funding for a trial that we can quickly roll out to all NHS hospitals.
Who can take part
Inclusion criteria
- Have a rectal tumour or suspected tumour less than or equal to T3b on MRI stage or pT2 or less after excision, or 20mm or more on endoscopy with suspicion of malignancy
- Be aged 16 years or over
Exclusion criteria
- Have metastatic disease at time of initial staging
- Have a biopsy-proven rectal malignancy which is not adenocarcinoma
- Are contraindicated for MRI
Where it is running
23 locations listed.
- St Marks Bowel Cancer Screening Centre - Harrow, United Kingdom
- Royal Berkshire Hospital - Reading, Berkshire, United Kingdom
- Buckinghamshire Healthcare Nhs Trust - Amersham, Buckinghamshire, United Kingdom
- University College London Hospitals Nhs Foundation Trust - London, Greater London, United Kingdom
- King'S College Hospital Nhs Foundation Trust - London, Greater London, United Kingdom
- West Middlesex Hospital - London, Greater London, United Kingdom
- Imperial College Healthcare Nhs Trus - London, Greater London, United Kingdom
- The Hillingdon Hospitals Nhs Foundation Trust - Uxbridge, Greater London, United Kingdom
- Hampshire Hospitals Nhs Foundation Trust - Basingstoke, Hampshire, United Kingdom
- Southampton General Hospital - Southampton, Hampshire, United Kingdom
- Kent & Canterbury Hospital - Canterbury, KENT, United Kingdom
- Maidstone Hospital - Maidstone, KENT, United Kingdom
- Westmorland General Hospital - Kendal, Lancashire, United Kingdom
- Leicester Royal Infirmary - Leicester, Leicestershire, United Kingdom
- St George'S Hospital - Tooting, London, United Kingdom
- John Radcliffe Hospital - Oxford, Oxfordshire, United Kingdom
- Nhs Staffordshire and Stoke-on-Trent Integrated Care Board - Stafford, Staffordshire, United Kingdom
- Frimley Health Nhs Foundation Trust - Camberley, Surrey, United Kingdom
- St Helier Hospital - Carshalton, Surrey, United Kingdom
- Kingston Hospital Nhs Foundation Trust - Kingston upon Thames, Surrey, United Kingdom
- Croydon Health Services Nhs Trust - Thornton Heath, Surrey, United Kingdom
- Tonna Hospital - Swansea, Wales, United Kingdom
- Salisbury District Hospital - Salisbury, Wiltshire, United Kingdom