Clinical and Imaging Cohort of Neuroinflammation Diseases in China (CLUE)
Recruiting · NCT04106830 · Observational (researchers observe without assigning treatment) · Lead sponsor: Beijing Tiantan Hospital
View the official record on ClinicalTrials.gov →Interventions studied
Intravenous steroid
What this trial is about
CLUE is a prospective study to assess structural and functional changes of the brain, spinal cord, and optic nerve, as well as the inflammatory environment in patients with neuroinflammatory and demyelinating diseases. Participants will receive magnetic resonance (MR) techniques including DIR, DKI, QSM, Rs-fMRI, conventional sequences (T1WI/T2WI/FLAIR), and the MR metabolic SPICE sequence, and will be followed up for one year using 3T MRI. In addition, participants will receive a one-time baseline examination including T1WI, T2WI, FLAIR, and SWI sequences on 7T MRI, as well as PET-MRI.
Who can take part
Age range
16 Years to 75 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- 16-75
- Diagnosis of neuroinflammatory and demyelination disease
- Availability of demographic and clinical data at the time disease onset
- Informed written consent obtained from the patient, and/or patient's parent(s), and/or legal representative. Assent, if old enough to grant, will be obtained from all patients under the age of 16 years.
Exclusion criteria
- Patients for whom MRI is contra-indicated
- Patients included in an ongoing clinical trial where the product is blinded
Where it is running
1 location listed.
- Beijing Tiantan Hospital - Beijing, Beijing Municipality, China