Skeletal Muscle Energetics and Fatiguability in Older Individuals
Recruiting · NCT04142047 · Observational (researchers observe without assigning treatment) · Lead sponsor: Johns Hopkins University
View the official record on ClinicalTrials.gov →What this trial is about
The investigators are studying whether metabolic abnormalities in calf (leg) muscle in older people with and others without HIV are associated with decreased abilities to exercise.
Who can take part
Age range
60 Years to 90 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Participants who are \>= 60 years of age
- HIV serostatus positive participants on stable antiretroviral therapy (ART) (no regimen change in last month) with undetectable HIV viral load (\<100 copies).
- HIV serostatus negative participants
Exclusion criteria
- Unable to understand the risks, benefits, and alternatives of participation and give meaningful consent
- Contraindications to MRI
- Significant cardiovascular, pulmonary or musculoskeletal or orthopedic disease that significantly limits exercise capacity
- Significant lower extremity peripheral vascular disease.
- Weight greater than 350 lbs
- Cognitive or speech impairments that would limit completion of questionnaires or fatigue reporting.
Where it is running
1 location listed across 1 US state.
- Johns Hopkins Hospital - Baltimore, Maryland, United States