Investigating the Link Between Type 2 Immunity and NAFLD in Human Obesity
Recruiting · NCT04232566 · Observational (researchers observe without assigning treatment) · Lead sponsor: Mayo Clinic
View the official record on ClinicalTrials.gov →Interventions studied
Bariatric surgery
What this trial is about
This study is being done to better understand the relationship between inflammation in adipose tissue (AT), abnormal deposition of fat around the liver and how this affects its appearance and function and ultimately insulin resistance.
Who can take part
Age range
30 Years to 70 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Undergoing gastric bypass surgery
- Confirmed AUROC F=0 or F\>2 liver fibrosis
- Age 30-70 years
- BMI greater than 40 kg/m2
- Negative pregnancy test (female only)
- Lab Values: Normal TSH
Exclusion criteria
- Autoimmune diseases
- Hepatitis B or C positive
- Heavy alcohol use
- Active smoking history
- Active cancer history
- History of asthma
- History of COPD
- Taking Plavix or Coumadin
- Blood donation within past 2 months
- Glucocorticoid Therapy
- Taking antihistamine on regular basis
Where it is running
1 location listed across 1 US state.
- Mayo Clinic in Arizona - Scottsdale, Arizona, United States