Cardiotoxicity Assessment Through Comprehensive Heart Imaging to Predict Heart Failure
Recruiting · NCT04262830 · Observational (researchers observe without assigning treatment) · Lead sponsor: Hari Narayan
View the official record on ClinicalTrials.gov →Interventions studied
Accelerometer physical activity monitoringCardiac magnetic resonance imaging (MRI)
What this trial is about
Anthracycline chemotherapies (e.g. doxorubicin, daunorubicin) are commonly given to treat pediatric cancer, and carry a risk of cardiotoxicity. Over the long term, children who receive these therapies have an increased risk of heart failure and early cardiovascular death. However, current strategies for identifying patients who are at risk prior to the development of significant changes in heart function are limited. This study will focus on imaging markers of cardiac injury and dysfunction with the goal of developing improved diagnostic tests and treatment strategies.
Who can take part
Age range
13 Years to 39 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- English and Spanish speaking male and female subjects, ages 13-39 years old
- Diagnosis of cancer at age \<22 years
- Previously treated with anthracyline therapy for cancer, with diagnosis at least two years prior.
Exclusion criteria
- Patients who have a contraindication to cardiac MRI, including the presence of non-MRI compatible metallic implants.
- Medical, psychiatric, and/or social disorder that would prevent successful completion of planned study testing or would preclude the subject from undergoing the cardiac MRI without anesthesia.
- Patients with a history of congenital heart disease (more significant than a history of patent foramen ovale or patent ductus arteriosus).
- Pregnancy (at the time of enrollment).
Where it is running
1 location listed across 1 US state.
- Rady Children's Hospital - San Diego, California, United States