Chronic Hypertension and Acetyl Salicylic Acid in Pregnancy

Inclusion criteria

• Pregnant patient between 10 and 19 weeks of gestation + 6 days
• Chronic hypertension, whether treated or not, know before pregnancy or diagnosed before randomization
• Singleton pregnancy
• Signed the written informed consent
• Affiliation to social security

Exclusion criteria

• ---Medical history requiring anticoagulation (antiphospholipid syndrome, deep vein thromboembolic disease, pulmonary embolism, atherothrombosis, patient with mechanical heart valves),
• Patient receiving aspirin for another indication outside pregnancy,
• Patient with significant proteinuria (\> 300mg/24 hours or a proteinuria/creatininuria ratio ≥ 30mg/mmol),
• Active bleeding,
• History of severe PE with delivery \< 34 weeks of gestation,
• Hypersensitivity to salicylates such as aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs),
• Platelet count lower than 100,000 cells/microliter (dosage less than 6 months old),
• Hemostasis disorders, including hemophilia (with thrombocytopenia)
• Any constitutional or acquired hemorrhagic disease, (including digestive hemorrhages, history of hemorrhagic stroke and thrombocytopenia
• Human immunodeficiency virus, or hepatitis B virus, or hepatitis C virus positive serum,
• Patient included in another interventional study which could interfere with the results of the study,
• Age \<18 years old,
• Women under the protection of justice,
• Patients with psychiatric follow-up, poor understanding of French or cognitive problems,
• Duodenal ulcer,
• Severe renal impairment,
• Severe hepatic insufficiency,
• Severe cardiac impairment,
• Gout,
• Patients with known glucose-6-phosphate dehydrogenase deficiency,