ASPIrin in Reducing Events in Dialysis ( ASPIRED )
Recruiting · NCT04381143 · Interventional (participants receive a specific treatment) · Lead sponsor: Guangdong Provincial People's Hospital
View the official record on ClinicalTrials.gov →Interventions studied
Aspirin 100 mg Oral TabletMatching Placebo
What this trial is about
People with kidney failure requiring dialysis have a much higher risk of developing cardiovascular (CV) disease compared with the general population. A cardiac cause accounts for 58% of all deaths in patients with end stage kidney disease (ESKD). At the same time, this population has increased risks of clotting as well as bleeding episodes. While aspirin is known to reduce cardiovascular complications in the general population, evidence to support the use of aspirin in people with ESKD receiving dialysis therapy is currently lacking. The ASPIrin to Reduce Event in Dialysis (ASPIRED) trial will test whether aspirin use in dialysis patients safely improves outcomes compared with no aspirin use.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Phase 4
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Incident or prevalent adults (≥18 years old) dialysis patients are included in the Dialysis Registry.
- Commenced on dialysis with the expectation of ongoing maintenance dialysis requirement.
- Willing and able to provide informed consent for this study.
Exclusion criteria
- Requirement for any form of antiplatelet agent (aspirin, glycoprotein IIb/IIIa inhibitors etc), or oral anticoagulation (warfarin, NOACs), in the view of the treating physician.
- Contraindication to aspirin, in the view of the treating physician.
- Dialysis requirement due to acute kidney injure with expectation of kidney function recovery.
- History of haemorrhagic stroke or intracranial bleed within 12 months of screening.
- Coagulopathy from any cause.
- Unable to provide informed consent.
Where it is running
60 locations listed.
- The First Affiliated Hospital of Fujian Medical University - Fuzhou, Fujian, China
- Shanghang County Hospital - Longyan, Fujian, China
- The First Hospital of Lanzhou University - Lanzhou, Gansu, China
- Dongguan Donghua Hospital - Dongguan, Guangdong, China
- Dongguan Hospital of Integrative Traditional Chinese and Western Medicine - Dongguan, Guangdong, China
- Dongguan Houjie Hospital - Dongguan, Guangdong, China
- Dongguan Eighth People's Hospital - Dongguan, Guangdong, China
- Dongguan Marina Bay Center Hospital - Dongguan, Guangdong, China
- Dongguan People's Hospital - Dongguan, Guangdong, China
- Dongguan Songshan Lake Center Hospital - Dongguan, Guangdong, China
- Lufeng People's Hospital - Donghai, Guangdong, China
- Foshan Gaoming District People's Hospital - Foshan, Guangdong, China
- The Second People Hospital of Foshan Nanhai - Foshan, Guangdong, China
- Foshan Nanhai District People's Hospital - Foshan, Guangdong, China
- Foshan No.1 people's hospital - Foshan, Guangdong, China
- Foshan Sanshui People's Hospital - Foshan, Guangdong, China
- Foshan Second People's Hospital - Foshan, Guangdong, China
- Guangdong Provincial Hospital of Integrative Medicine - Foshan, Guangdong, China
- The Third Affiliated Hospital of Southern Medical University - Guangzhou, Guangdong, China
- The First Affiliated Hospital of Guangdong Medical University - Guangzhou, Guangdong, China
- Sun Yat-sen Memorial Hospital - Guangzhou, Guangdong, China
- Guangzhou Redcross Hospital - Guangzhou, Guangdong, China
- Zhujiang Hospital of Southern Medical University - Guangzhou, Guangdong, China
- Guangdong Provincial Hospital of Traditional Chinese Medicine Fangcun Branch (Guangzhou Charity Hospital) - Guangzhou, Guangdong, China
- The First Affiliated Hospital of Jinan University - Guangzhou, Guangdong, China
- The Fifth Affiliated Hospital of Southern Medical University - Guangzhou, Guangdong, China
- Guangdong Agricultural Reclamation Central Hospital - Guangzhou, Guangdong, China
- Guangdong Cliffod Hospital - Guangzhou, Guangdong, China
- Guangdong Provincial Peoples Hospital - Guangzhou, Guangdong, China
- Guangzhou First People's Hospital - Guangzhou, Guangdong, China
- Hua Du District People's Hospital of Guangzhou - Guangzhou, Guangdong, China
- Panyu District people's hospital of Guangzhou - Guangzhou, Guangdong, China
- The Fifth Affiliated Hospital of Guangzhou Medical University - Guangzhou, Guangdong, China
- The First Affiliated Hospital of Guangzhou University of Chinese Medicine - Guangzhou, Guangdong, China
- The Sixth Affiliated Hospital of Sun yat-sen University - Guangzhou, Guangdong, China
- The Third Affiliated Hospital of Sun Yat-sen University - Guangzhou, Guangdong, China
- The First Affiliated Hospital of Sun Yat-sen University - Guanzhou, Guangdong, China
- Heyuan People's Hospital - Heyuan, Guangdong, China
- Huizhou First People Hospital - Huizhou, Guangdong, China
- Huizhou Central People's Hospital - Huizhou, Guangdong, China
- The People's Hospital of Jiangmen - Jiangmen, Guangdong, China
- Jiangmen Center hospital - Jiangmen, Guangdong, China
- Jieyang People's Hospital - Jieyang, Guangdong, China
- Kaiping Center Hospital - Kaiping, Guangdong, China
- Lianjiang People's Hospital - Lianjiang, Guangdong, China
- Lianping County People's Hospital - Lianping, Guangdong, China
- The Fourth Affiliated Hospital of Guangzhou Medical University - Licheng, Guangdong, China
- Maoming Hospital of Traditional Chinese Medicine - Maoming, Guangdong, China
- Maoming People's Hospital - Maoming, Guangdong, China
- Meizhou People's Hospital - Meizhou, Guangdong, China
- The Third Affiliated Hospital of Sun Yat-sen University Yuedong Hospital - Meizhou, Guangdong, China
- Puning People's Hospital - Puning, Guangdong, China
- Qingyuan People's Hospital - Qingyuan, Guangdong, China
- Fogang People Hospital - Qingyuan, Guangdong, China
- Qingyuan Hospital of Traditional Chinese Medicine - Qingyuan, Guangdong, China
- The Second Affiliated Hospital of Shantou University Medical College - Shantou, Guangdong, China
- The first Affiliated Hospital of Shantou Medical University - Shantou, Guangdong, China
- Shantou Chaonan Minsheng Hospital - Shantou, Guangdong, China
- Shanwei People's Hospital - Shanwei, Guangdong, China
- Shenshan Medical Center, Memorial Hospital of Sun Yat-sen University - Shanwei, Guangdong, China
Showing 60 of 139 listed sites. See the official record for the complete list.
Read the full protocol, contacts and eligibility on ClinicalTrials.gov →