Inhaled and Intravenous Milrinone in Patients With Severe Pulmonary Hypertension
Recruiting · NCT04484675 · Interventional (participants receive a specific treatment) · Lead sponsor: Zagazig University
View the official record on ClinicalTrials.gov →Interventions studied
Milrinone infusionMilrinone inhalation
What this trial is about
The investigator compared difference between inhaled and intravenous milirinone in patiens with severe pulmonary hypertension undergoing cardiac surgery
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Phase 4
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Patients scheduled to undergo mitral valve surgery by cardiopulmonary bypass with estimated mean pulmonary artery pressure =\>55 estimated by using preoperative Doppler echocardiography
Exclusion criteria
- Patients were excluded if they had surgery without CPB, preoperative hemodynamic instability (defined as acute requirement for vasoactive support or mechanical device),Patients with severe LV dysfunction (LV ejection fraction of less than 30% congenital heart disease, a contraindication to transesophageal echocardiography (TEE), emergency surgery or re-do surgeries severe renal or hepatic disease
- , coagulopathy, and thromboembolic disease treated with anticoagulants
Where it is running
1 location listed.
- Zagazig University - Zagazig, Sharqia Province, Egypt