Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents With Crohn Disease
Recruiting · NCT04508088 · Observational (researchers observe without assigning treatment) · Lead sponsor: Massachusetts General Hospital
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
The investigators will be evaluating bone marrow composition via magnetic resonance imaging in newly diagnosed adolescents with Crohn disease (CD) compared to healthy, matched controls. The investigators will also be assessing their bone mineral density via other imaging modalities, including dual-energy X-ray absorptiometry and peripheral quantitative computed tomography. This longitudinal project will focus on abnormalities in bone marrow composition, and specifically whether adolescents with newly diagnosed CD exhibit increased bone marrow fat, its association with bone mineral density (BMD) and the underlying pathophysiology, including bone turnover markers and immune cellular/molecular parameters.
Who can take part
Inclusion criteria
- Crohn's Disease diagnosed within the past 3 months, or a healthy, matched control
Exclusion criteria
- Participants with chronic disease known to affect skeletal metabolism
- Participants on certain medications within the prior 3 months that are known to affect skeletal metabolism
- Participants who are pregnant
- Participants who have a history of: claustrophobia, internal body metal that is not compatible with MRI machine, or a known abnormality on or adjacent to the left knee
Where it is running
1 location listed across 1 US state.
- Boston Children's Hospital - Boston, Massachusetts, United States