Study on Biomarkers for Early Diagnosis of Alzheimer's Disease
Recruiting · NCT04575337 · Observational (researchers observe without assigning treatment) · Lead sponsor: Capital Medical University
View the official record on ClinicalTrials.gov →What this trial is about
The project of Bio-AD is a population- based cohort study among the elderly in China. The project includes not only Alzheimer's disease (AD including familial AD and sporadic AD), but also other clinical stage of AD, as well as elderly people with normal cognitive function. The project will collect, detect and screen the special biomarkers at different clinical stage of AD based on body fluid, gene and brain image. The standard and consistent assessment protocols are employed to obtain clinical, cognitive, genetic, neuroimaging and biospecimen data. The purpose of this project is to establish a panel of biomarkers which could be used to diagnose AD at the early stage, and to establish a risk prediction models for AD to predict the 5-years risk of the onset and progression of AD among elderly population in China.
Who can take part
Inclusion criteria
- Written informed consent obtained from participant or legal guardian prior to any study-related procedures.
- Aged 18 (inclusive) or older.
- Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-R). The diagnosis of AD is made using the National Institute of Neurologic and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS- ADRDA) or National Institute on Aging and the Alzheimer's Assocation (NIA-AA) criteria. A diagnosis of mild cognitive impairment (MCI) is assigned according to Petersen criteria. A diagnosis of pre-MCI group is assigned by β-Amyloid positive or APOE ε4 carrier or complains of cognitive impairment, but not up to MCI or cognitive impairment. Normal cognitive function assessed/evaluated by MMSE, CDR and other cognitive function scales.
- Follow up 5 years and collect the information.
Exclusion criteria
- Under age 18.
- Medical or psychiatric illness that would interfere in completing initial and follow-up visits.
- No one can serve as a study informant.
- With current or past neurological or psychiatric illnesses such as schizophrenia, epilepsy, brain tumors, severe head trauma and other diseases which can induce dementia.
- Refused to complete a cognitive test and provide biospecimen.
- With history of alcohol or drug abuse.
Where it is running
1 location listed.
- Xuanwu Hospital of Capital Medical University - Beijing, Beijing Municipality, China