Integrated Patient Avatars for Guiding Systemic Therapy Treatments in Metastatic Breast Cancer Patients
Recruiting · NCT04608357 · Observational (researchers observe without assigning treatment)
View the official record on ClinicalTrials.gov →Interventions studied
Needle Core Biopsies
What this trial is about
The investigators propose to use clinically validated patient avatar technology ("PDXovo") that can test multiple drugs against patients' cancers to identify the most promising systemic therapy for each individual.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Age 18+.
- Metastatic breast cancer irrespective of subtype.
- Measurable disease as per RECIST 1.1 criteria.
- Metastatic disease involving the lymph nodes and/or visceral organs is required.
- Willingness to undergo a biopsy prior to the start of planned systemic therapy.
Exclusion criteria
- Lack of feasibility to obtain a core biopsy of a metastatic site other than the bone (e.g. a metastatic lesion cannot be safely sampled due to proximity to vasculature).
- Inability to provide informed consent.
Where it is running
1 location listed.
- Sunnybrook Health Sciences Centre - Toronto, Ontario, Canada