Mediastinal Lymph Node Dissection Versus Spared Mediastinal Lymph Node Dissection in Stage I GGN NSCLC
Recruiting · NCT04631770 · Interventional (participants receive a specific treatment) · Lead sponsor: Tianjin Medical University Cancer Institute and Hospital
View the official record on ClinicalTrials.gov →Interventions studied
Spared mediastinal lymph node dissectionSystemic mediastinal lymph node dissection
What this trial is about
Lung cancer is the leading cause of cancer related death worldwide. Lobectomy or sub-lobectomy with mediastinal lymph node dissection is the standard surgery. About 50% lung nodules are pure ground-glass or part-solid nodules. Non-solid nodules rarely develop mediastinal lymph node metastasis. The present study is a prospective, multicenter and randomized clinical trial, comparing the overall survival and disease-free survival of whether performing mediastinal lymph node dissection in non-small cell lung cancer with ground-glass nodule CT features.
Who can take part
Age range
No age limits stated
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Thin-slice HRCT shows single GGN with C/T ≤ 0.5 and no lymph node metastasis;
- Clinical stage IA NSCLC (TNM 8th classification) diagnosed prior or in surgery;
- No history of malignancies within past 5 years or lung surgery;
- No anti-cancer treatment prior to surgery.
Exclusion criteria
- Simultaneous or metachronous (within the past 5 years) double cancers;
- Active bacterial or fungous infection;
- Interstitial pneumonitis, pulmonary fibrosis, or severe pulmonary emphysema;
- Systemic steroidal medication;
- Uncontrollable diabetes mellitus; (vi) Uncontrollable hypertension or history of severe heart disease, heart failure.
Where it is running
1 location listed.
- Ethics review board of Tianjin Medical University Cancer Institute and Hospital - Tianjin, Tianjin Municipality, China