Integrated Diagnostics for Early Diagnosis of Liver Disease
Recruiting · NCT04666402 · Observational (researchers observe without assigning treatment) · Lead sponsor: Manchester University NHS Foundation Trust
View the official record on ClinicalTrials.gov →Interventions studied
Blood tests for Single Nucleotide PolymorphismsFaecal microbiome analysisSerum for diagnostic biomarkers
What this trial is about
This is an observational study that will explore the hypothesis that by combining data from patients with liver disease with novel blood biomarkers, single nucleotide polymorphism (SNP) analysis and faecal microbiome analysis. The Investigators will improve diagnosis of liver fibrosis compared to the current available diagnostic tools.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- All patients referred to Community Liver Assessment Clinic.
- Male or female \> 18 years of age.
- Females will be non-pregnant and non-lactating.
Exclusion criteria
- Age \< 18 years.
- Pregnancy/breast-feeding. Women of childbearing potential (not \>2 years post- menopausal and/or not surgically sterilised) must have a negative blood serum pregnancy test.
- Isolated bilirubinaemia.
- Known pre-existing liver disease.
- Acutely unwell.
- Suspected malignancy.
Where it is running
1 location listed.
- Manchester University NHS Foundation Trust - Manchester, Greater Manchester, United Kingdom