Functional Lung Avoidance SPECT-guided Radiation Therapy of Lung Cancer
Recruiting · NCT04676828 · Interventional (participants receive a specific treatment) · Lead sponsor: University of Aarhus
View the official record on ClinicalTrials.gov →Interventions studied
Single-photon-emission CT scan
What this trial is about
Study aims to determine if functional lung avoidance based on perfusion single photon emission (SPECT)/CT scan, improves toxicity outcomes for patients with advanced lung cancer undergoing chemo-radiotherapy. Functional avoidance implies a dose plan that takes functional distribution in the lung into account, and avoids highly functional lung volumes sparing them from radiation.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- histologically verified lung cancer (small-cell and non-small cell lung cancer)
- referred for radiotherapy with curative intent
- radiation dose of 60-66 Gy given in 2-Gy fractions, other dose levels and fractionation schedules accepted, as per site standard
- concurrent chemotherapy is accepted
- patients with oligometastatic disease are allowed, where metastasis have been ablated with surgery or radiotherapy
- receiving (chemo)-radiotherapy to the thoracic disease with curative intent
- adults over 18, that have given oral and written informed consent before patient registration.
Exclusion criteria
- concurrent immunotherapy
- previous radiotherapy to the thorax
- other uncontrolled malignancies; any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol
Where it is running
2 locations listed.
- Department of Oncology, Aarhus University Hospital - Aarhus, Denmark
- Sydney West Radiation Oncology Network Westmead and Blacktown Hospitals - Sydney, New South Wales, Australia