A Personalized Surveillance and Intervention Protocol for Patients With Familial Adenomatous Polyposis That Have Undergone (Procto)Colectomy
Recruiting · NCT04678011 · Observational (researchers observe without assigning treatment) · Lead sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
View the official record on ClinicalTrials.gov →Interventions studied
Personalized surveillance and intervention protocol
What this trial is about
The purpose of this study is to determine the efficacy and safety of a personalised surveillance and intervention protocol for patients with familial adenomatous polyposis (FAP) that have undergone (procto)colectomy.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Diagnosis of FAP, at least one of following: genetic diagnosis (proven APC germline mutation) and/or clinical diagnosis (\>100 colorectal adenomas in combination with a positive family history of FAP)
- Have undergone prophylactic (procto)colectomy with IRA/ISA or IPAA
- Age 18 years or older
Exclusion criteria
- Not able to remove all polyps with an indication for removal during (multiple) clearing endoscopies
- Cancer at baseline endoscopy
- Need for surgery
Where it is running
2 locations listed across 1 US state.
- MD Anderson - Houston, Texas, United States
- Academic Medical Centre - Amsterdam, North Holland, Netherlands