Anatomical Resection of Liver MetAstases iN patIents With RAS-mutated Colorectal Cancer
Recruiting · NCT04678583 · Interventional (participants receive a specific treatment)
View the official record on ClinicalTrials.gov →Interventions studied
Resection of colorectal liver metastases
What this trial is about
the ARMANI trial will test the hypothesis, if an anatomic resection (AR) improves long-term outcome vs. a non-anatomical resection (NAR) in patients undergoing surgery for RAS-mutated colorectal liver metastasis (CRLM).
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Colorectal cancer with RAS mutation (KRAS or NRAS)
- Colorectal liver metastases (single or multiple)
- Planned R0 resection of liver metastases (and primary tumor, if present)
- Anatomical and non-anatomical liver resection technically feasible
- Male and female patients, age ≥ 18 years
- Written informed consent
Exclusion criteria
- Extrahepatic metastases
- Planned staged liver resection (e.g. two-stage hepatectomy)
- Diagnosis of another cancer \< 5 years prior to randomization Exceptions: curatively treated in situ cervical cancer, curatively resected non-melanoma skin cancer
- Expected lack of compliance
- Addiction or other illnesses which do not allow the person concerned to assess the nature and extent of the clinical trial and its possible consequences
Where it is running
37 locations listed.
- Intestinal Center West Middle Franconia, ANregiomed Clinic Ansbach - Ansbach, Germany
- Clinic for General, Vizeral and Transplant Surgery, Augsburg University Hospital - Augsburg, Germany
- Department of General, Visceral and Vascular Surgery, Charité, University Medicine Berlin, Campus Benjamin Franklin Berlin - Berlin, Germany
- Clinic and Polyclinic for General, Visceral, Thoracic and Vascular Surgery, University Hospital Bonn - Bonn, Germany
- Surgical Clinic, Municipal Hospital Braunschweig gGmbH - Braunschweig, Germany
- Cancer Center, Helios Amper-Hospital Dachau - Dachau, Germany
- Surgical Clinic, Dortmund Hospital - Dortmund, Germany
- Clinic for General and Visceral Surgery, Municipal Hospital Dresden - Dresden, Germany
- Clinic for General, Visceral and Pediatric Surgery, University Hospital Düsseldorf - Düsseldorf, Germany
- Surgical Clinic, University Hospital Erlangen - Erlangen, Germany
- Clinic for General, Visceral and Transplant Surgery, University Hospital Frankfurt, Goethe University Frankfurt am Main - Frankfurt, Germany
- Department for General and Visceral Surgery, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg - Freiburg im Breisgau, Germany
- JLU Gießen, Department for General, Visceral, Thoracic and Transplant Surgery - Giessen, Germany
- Clinic and Polyclinic for General Surgery, Department of Gastrointestinal, Thoracic and Vascular Surgery, University Greifswald, University Hospital Greifswald - Greifswald, Germany
- Clinic for General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Georg-August-University - Göttingen, Germany
- University Hospital and Polyclinic for Visceral, Vascular and Endocrine Surgery, University Hospital Halle (Saale) - Halle, Germany
- Center for Surgical Medicine - Clinic and Polyclinic for General, Visceral and Thoracic Surgery, University Hospital Hamburg-Eppendorf - Hamburg, Germany
- Department of Liver, Bile Duct and Pancreas Surgery, University Department of surgery, Asklepios Klinik Barmbek - Hamburg, Germany
- Clinic for General, Visceral and Minimally Invasive Surgery, KRH Clinic Siloah, Hannover - Hanover, Germany
- Medizinische Hochschule Hannover, Department of General, Visceral and Transplant Surgery - Hanover, Germany
- Department of General, Visceral and Transplantation Surgery, University of Heidelberg - Heidelberg, Germany
- General Visceral and Vascular Surgery, Jena University Medical Center - Jena, Germany
- Clinic for Surgery, University Hospital Schleswig-Holstein Lübeck Campus - Lübeck, Germany
- University Department of General, Visceral, Vascular and Transplant Surgery, Faculty of Medicine, Otto von Guericke University Magdeburg - Magdeburg, Germany
- Clinic for General, Visceral and Transplantation Surgery, University Medical Center of the Johannes Gutenberg-University Mainz - Mainz, Germany
- Clinic for Visceral, Thoracic and Vascular Surgery, University Hospital Giessen and Marburg - Marburg, Germany
- LMU Munich Hospital, Clinic for General, Visceral and Transplant Surgery - Munich, Germany
- Department Hepato-Pancreato-Biliary Surgery, Barmherzige Brüder gGmbH of the Hospital Barmherzige Brüder Munich - München, Germany
- Department of Surgery, University Hospital rechts der Isar - München, Germany
- Clinic for General, Visceral and Transplant Surgery, University of Münster - Münster, Germany
- University Hospital for General and Visceral Surgery, Oldenburg Hospital - Oldenburg, Germany
- Department of General, Visceral and Transplant Surgery, University of Tübingen, Comprehensive Cancer Center - Tübingen, Germany
- Clinic for General and Visceral Surgery, Ulm University Medical Center - Ulm, Germany
- General and Visceral Surgery, Helios University Medical Center Wuppertal, University Witten/Herdecke - Wuppertal, Germany
- Department for General, Visceral, Transplant, Vascular and Pediatric Surgery, Julius-Maximilian-University Würzburg, University Hospital Würzburg - Würzburg, Germany
- Department of Surgery at the University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University - Mannheim, Baden-Wurttemberg, Germany
- Department of Gastrointestinal-, Thoracic and Vascular Surgery University Hospital Carl Gustav Carus Technische Universität Dresden - Dresden, Saxony, Germany