Image-guided Computational and Experimental Analyses of Fractured Patient's Bone (GAP)
Recruiting · NCT04787679 · Observational (researchers observe without assigning treatment) · Lead sponsor: Laura Maria Vergani
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
Due to the increase in the average age of the population, the projections on the number of age-dependent bone fractures appear to be constantly increasing. They are mainly due to bone pathologies, including osteoporosis. The latter leads to a reduction in bone mineral density and deterioration of the micro-architecture, with a consequent increase in bone fragility. However, the mechanisms of damage at the micro-scale have not yet been elucidated and there is no universally recognized damage criterion. Recent research has evaluated the importance of implementing computational models to study the influence of bone gaps, canaliculi and microporosities on the propagation of damage. These models need to be validated through experimental tests, still lacking, in particular on human bones, in the current scientific landscape. Once the experimental validation of computational models has been developed, it will be possible to introduce new fracture indices at the micro-scale, useful for a preventive diagnosis of osteoporosis.
Who can take part
Inclusion criteria
- Age: \>=18 years
- primary hip replacement
- Signature of informed consent
- Patients who have a routine preoperative CT scan
Exclusion criteria
- Patients unrelated to the inclusion criteria of this study
- Bone disease (non-osteoporotic) such as to invalidate sample analysis, including but not limited to genetic disorders and bone tumors
- Patients with contralateral hip replacement and/or other synthetic means in the contralateral hip
- Patients with synthesis devices in the hip of interest
Where it is running
1 location listed.
- IRCCS Istituto Ortopedico Galeazzi - Miano, Milano, Italy