Modeling the Effects of Chronic Marijuana Use on Neuroinflammation and HIV-related Neuronal Injury
Recruiting · NCT04810858 · Interventional (participants receive a specific treatment) · Lead sponsor: Wake Forest University Health Sciences
View the official record on ClinicalTrials.gov →Interventions studied
Immune and cytokine profilingMultimodal, multi-parametric MRINeuropsychological testing
What this trial is about
This study applies a hypothesis-driven approach to examine the effects of chronic marijuana use on HIV-associated inflammation and its subsequent impacts on central nervous system function, with the goal of identifying the mechanisms through which cannabinoids modulate neurological disorders and other comorbidities in persons with HIV.
Who can take part
Age range
25 Years to 59 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- verified HIV status
- Current marijuana use (MJ+ groups only)
- No current marijuana use (MJ- groups only)
- current engagement in HIV care (HIV+ participants only)
- receipt of cART as first-line of treatment (HIV+ participants only)
- stable cART regimen (HIV+ participants only)
- undetectable HIV RNA viral load for \>1 year (HIV+ participants only)
Exclusion criteria
- Lifetime abuse for any illicit drug other than marijuana
- \<9th grade education; illiteracy or lack of fluency in English
- history of moderate or severe head trauma
- unstable or serious neurological disorders
- severe mental illness
- systemic autoimmune diseases
- immunotherapy
- MRI contraindications
Where it is running
1 location listed across 1 US state.
- Biotech Place - Winston-Salem, North Carolina, United States