Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness
Recruiting · NCT04940663 · Interventional (participants receive a specific treatment) · Lead sponsor: Massachusetts General Hospital
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
The proposed research will test the hypothesis that objective social isolation and loneliness are linked to neurobehavioral mechanisms involved in social perception and motivation in individuals with and without serious mental illness. Moreover, it will investigate the specific dynamic interactions among these experiences in daily life and how they, and their neurobehavioral predictors, are linked to day-to-day functioning. The findings of this project could provide novel targets for therapeutics aimed at improving functioning and overall quality of life in individuals with serious mental illnesses, as well as quantitative phenotypes for use in early detection efforts.
Who can take part
Inclusion criteria
- 18-55 years old
- Experienced a psychotic disorder or mood disorder
Exclusion criteria
- Any neurological disorder or current substance use disorder (during the past 6 months)
- Not proficient in English
- A recent change in medication, or an acute symptom presentation
- Standard exclusion criteria for participation in an MRI scan (e.g., presence of metal in the body, claustrophobia, a history of head trauma).
Where it is running
1 location listed across 1 US state.
- Massachusetts General Hospital - Charlestown, Massachusetts, United States