Xenon MRI Pulm Hypertension

Inclusion criteria

• f Cohort 1
• Subjects must meet all of the following inclusion criteria to be eligible for enrollment into the trial:
• Outpatients of either gender, Age 18-75
• Awaiting a lung transplant
• Diagnosis of precapillary PH (right heart catheterization demonstrating hemodynamic criteria of a mean pulmonary artery pressure (mPAP) ≥ 25 mmHg, pulmonary vascular resistance ≥ 3 WU, pulmonary capillary wedge pressure ≤ 15 mmHg) in the setting of Group 1 (PAH), 3 (PH due to chronic lung disease, 4 (PH due to pulmonary artery obstructions), or 5 (PH due to miscellaneous causes)
• Willing and giving informed consent and adhere to visit/protocol schedules (consent must be given before any study procedures are performed).
• Women of childbearing potential must have a negative urine pregnancy test before MRI

Exclusion criteria

• f Cohort 1
• Subjects presenting with any of the following will not be included in the trials:
• Moderate to severe heart disease (LVEF \<45%, Severe LV hypertrophy, Moderate to severe valvular disease)
• PH due to schistosomiasis
• Active cancer
• Sickle cell anemia
• Prisoners and pregnant women will not be approached for the study
• Conditions that will prohibit MRI scanning (metal in eye, claustrophobia, inability to lie supine)
• Medical or psychological conditions which, in the opinion of the investigator, might create undue risk to the subject or interfere with the subject's ability to comply with the protocol requirements
• Inclusion Criteria of Cohort 2
• Subjects must meet all of the following inclusion criteria to be eligible for enrollment into the trial:
• Treatment naïve or treatment started within the last 3 months
• Outpatients of either gender, Age 18-75
• WHO functional class (FC) 2-3 symptoms with a diagnosis of group 1 PH (mean pulmonary artery pressures (mPAP) \> 20 mmHg, pulmonary capillary wedge pressure (PCWP) ≤ 15mmHg and pulmonary vascular resistance (PVR) ≥3 WU)
• Willing and able to give informed consent and adhere to visit/protocol schedules (consent must be given before any study procedures are performed).
• Women of childbearing potential must have a negative urine pregnancy test before MRI
• Exclusion Criteria of Cohort 2
• Subjects presenting with any of the following will not be included in the trials:
• Sarcoidosis
• Active cancer
• Sickle cell anemia
• Liver disease (Childs-Pugh class C)
• Any conditions that prevent the performance of 129Xe MRI scans.
• Prisoners and pregnant women will not be approached for the study.
• Conditions that will prohibit MRI scanning (metal in eye, claustrophobia, inability to lie supine).
• Medical or psychological conditions which, in the opinion of the investigator, might create undue risk to the subject or interfere with the subject's ability to comply with the protocol requirements